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The Timing of Ribosomal RNA Modification During Eukaryotic Ribosome Biogenesis
The Timing of Ribosomal RNA Modification During Eukaryotic Ribosome Biogenesis
The Timing of Ribosomal RNA Modification During Eukaryotic Ribosome Biogenesis
Circular RNAs (circRNAs) are broadly expressed in eukaryotic cells, but their role in human health and disease remains obscure. Here, we show that circular antisense non-coding RNA in the INK4 locus (circANRIL), which is transcribed at a locus of atherosclerotic cardiovascular disease on chromosome ...
ORGANISM(S): Homo sapiens 
Cotranslational protein folding depends on general chaperones that engage highly diverse nascent chains at the ribosomes. It is not clear how this promiscuous mechanism ensure efficient production of challenging clients such as highly expressed proteins. Here we find that the biogenesis of the abund...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-06-16 | PXD043391 | Pride
hRNC XL-MS: Protein biogenesis begins on the ribosome where nascent chains are expressed vectorially from their N- to C-terminus, and start to fold as mRNA is translated. How the context of protein synthesis influences protein folding is poorly understood, especially in eukaryotes. Here we describe ...
ORGANISM(S): Homo sapiens (Human) 
2025-08-11 | PXD055251 | Pride
hRNC Proteomics - Protein biogenesis begins on the ribosome where nascent chains are expressed vectorially from their N- to C-terminus, and start to fold as mRNA is translated. How the context of protein synthesis influences protein folding is poorly understood, especially in eukaryotes. Here we des...
ORGANISM(S): Homo sapiens (Human) 
2025-08-11 | PXD055069 | Pride
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