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ProteomicsProteomic analysis of the secretome of Salmonella-infected Hela cells
It is becoming increasingly clear that cells infected with pathogens can signal to bystander cells. Infected cells have the ability to alert and instruct bystander cells to mount pro-inflammatory cytokine response, thus contributing to clearing infections. Here we analyse secretome of HeLa cells inf...
ORGANISM(S): Homo sapiens (Human) 
2021-04-16 | PXD018026 | Pride
Hela cells Salmonella Secretome 
TranscriptomicsTranscriptomic profiling of HeLa cells infected with Salmonella Typhimurium
We evaluated the transcriptome changes induced by infection with Salmonella (20 hpi, MOI 100). Transcriptmic profiles of HeLa cells infected with Salmonella Typhimurium were generated by deep sequencing, using Illumina HiSeq 2000.
ORGANISM(S): Homo sapiens 
2014-07-18 | E-GEOD-53280 | biostudies-arrayexpress
TranscriptomicsTranscript expression levels of neonatal mouse cardiomyocytes mock-transfected, or transfected with cel-miR-67, hsa-miR-590-3p or hsa-miR-199a-3p
To identify the relevant targets of the selected miRNAs, we assessed global transcriptome changes by deep-sequencing total neonatal mouse cardiomyocyte RNA after transfection with hsa-miR-590-3p or hsa-miR-199a-3p Four condition experiment; one replicate per condition; mouse neonatal cardiomyocytes ...
ORGANISM(S): Mus musculus 
2012-10-13 | E-GEOD-41538 | biostudies-arrayexpress
TranscriptomicsRNAi knock-down of CAF1-CCR4-NOT1 deadenylase complex or AGO1 in D. melanogaster S2 cells
miRNAs silence gene expression by repressing translation and/or by promoting mRNA decay. AGO1 is a key protein required for miRNA-mediated gene silencing. In animal cells, mRNA degradation of partially complementary miRNA targets occurs via deadenylation by the CAF1-CCR4-NOT1 deadenylase complex, fo...
ORGANISM(S): Drosophila melanogaster 
2008-12-03 | E-MEXP-1713 | biostudies-arrayexpress
TranscriptomicsAnalysis of the host microRNA response to Salmonella uncovers the control of major cytokines by the let-7 family
MicroRNAs have well-established roles in eukaryotic host responses to viruses and extracellular bacterial pathogens. In contrast, microRNA responses to invasive bacteria have remained unknown. Here, we report cell type-dependent microRNA regulations upon infection of mammalian cells with the enteroi...
ORGANISM(S): Mus musculus 
2011-03-10 | E-GEOD-27703 | biostudies-arrayexpress
TranscriptomicsTranscriptomic profiling of HeLa cells treated with miR-15a, miR-16, miR-503 and control-miR
To have a global picture of the targets of the miR-15 family, we assessed transcriptome changes, by deep-sequencing, of HeLa cells transfected with 3 members of the miR-15 family (miR-15a, miR-16 or miR-503) or a control miRNA (cel-miR-231). We observed a very extensive overlap between the genes dow...
ORGANISM(S): Homo sapiens 
2014-07-18 | E-GEOD-53279 | biostudies-arrayexpress
MetabolomicsSystematic identification of bacterial factors driving Staphylococcus aureus intracellular lifestyle in non-professional phagocytes

Staphylococcus aureus is a major human pathogen responsible for severe infections. While traditionally described as extracellular, increasing evidence establishes S. aureus as a facultative intracellular pathogen. Intracellularity contributes to immune evasion, dissemination, and antibiotic failu...

2025-10-26 | MTBLS13220 | MetaboLights
TranscriptomicsProfiling of miRNA expression of HeLa cells infected with Salmonella Typhimurium
We identified miRNAs differentially regulated upon Salmonella infection by comparative deep-sequencing analysis of cDNA libraries prepared from the small RNA population (10M-bM-^@M-^S29 nt) of HeLa cells infected with Salmonella (20 hpi) and mock-treated cells. Considering that at a MOI of 25 Salmon...
ORGANISM(S): Homo sapiens 
2014-07-18 | E-GEOD-53278 | biostudies-arrayexpress
UnknownStress-induced host membrane remodeling protects from infection by
Not available
S-SCDT-EMBOJ-2017-98529 | biostudies-other
TranscriptomicsMicroRNA expression in neonatal and adult rat cardiomyocytes
Expression profiles of microRNAs in neonatal (isolated from day0 newborn rats) and adult rat cardiomyocytes (isolated from 2month old rats) Two condition experiment; Biological replicates: 7 samples of cardiomyocytes from neonatal rats (from independent isolations); 6 samples of cardiomyocytes isola...
ORGANISM(S): Rattus norvegicus 
2012-10-13 | E-GEOD-41537 | biostudies-arrayexpress
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