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MetabolomicsMetabolomic Analysis Reveals an Important Role of Sphingosine 1-phosphate in the Development of HFMD due to EV-A71 Infection

Hand, foot, and mouth disease (HFMD) is a serious pediatric infectious disease that causes immeasurable physical and mental health burdens. Currently, there is a lack of information on the mechanisms of HFMD severity and early diagnosis. We performed metabolomic profiling of sera from 84 Enterovi...

2024-11-14 | MTBLS11656 | MetaboLights
ProteomicsRole of Rab11 in Enterovirus A71 (EV-A71) infection
A siRNA screening using a commercially available membrane trafficking library identified Rab11 as a pro-viral host factor in motor neuron NSC34 cell line infected with EV-A71, a major causative agent of Hand, Foot and Mouth Disease (HFMD). This project aims at deciphering the role of Rab11 during EV...
ORGANISM(S): Homo sapiens (Human) Enterovirus A71 
2024-06-28 | PXD043870 | Pride
Hfmd Enterovirus a71 (ev-a71) Rab11 
GenomicsTranscriptome analysis induced by EV-A71 infection
Transcriptome analysis induced by EV-A71 infection
PRJNA637599 | ENA
GenomicsRNA sequencing analysis of cells infected with chimeric EV-A71 strains in which the 3C protease region was swapped with other strains of EV-A71
RNA sequencing analysis of cells infected with chimeric EV-A71 strains in which the 3C protease region was swapped with other strains of EV-A71
PRJNA1406038 | ENA
TranscriptomicsRNA sequencing analysis of cells infected with chimeric EV-A71 strains in which the 3C protease region was swapped with other strains of EV-A71
The EV-A71 genome has accumulated mutations since the virus was first detected in 1969. To characterize the polymorphism of the EV-A71 3C protease, we performed RNA sequencing using chimeric EV-A71 strains carrying the 3C protease from a clinical strain. The chimeric EV-A71 was generated using a rev...
ORGANISM(S): Homo sapiens 
2026-02-12 | GSE317117 | GEO
UnknownA novel mucosal bivalent vaccine of EV-A71/EV-D68 adjuvanted with polysaccharides from Ganoderma lucidum protects mice against EV-A71 and EV-D68 lethal challenge.
Not available
S-EPMC10729491 | biostudies-literature
TranscriptomicsTranscriptomic Analysis Initially Reveals Monocyte/Macrophage Activation Drives EV-A71-Induced Immune Dysregulation and Neural Injury in Severe HFMD
Objective Enterovirus 71 (EV-A71) is a major pathogen of severe hand, foot and mouth disease (HFMD) in children, but the mechanism by which it develops into severe HFMD remains unclear, especially the role of macrophage-mediated immune dysregulation. Methods Macrophages infected with EV-A71 were col...
ORGANISM(S): Enterovirus A71 
2025-09-10 | GSE304239 | GEO
TranscriptomicsTranscriptome analysis induced by EV-A71 infection
In this study, we aimed to adopt the transcriptome sequencing technology to obtain the different changes of transcriptome profiles after infecting with EV-A71 in human neuroblastoma cell line SH-SY5Y. And then, through systematic bioinformatics analysis, we hope to find useful clues for the pathogen...
ORGANISM(S): Homo sapiens 
2023-06-05 | GSE151893 | GEO
GenomicsTranscriptomic Analysis Initially Reveals Monocyte/Macrophage Activation Drives EV-A71-Induced Immune Dysregulation and Neural Injury in Severe HFMD
Transcriptomic Analysis Initially Reveals Monocyte/Macrophage Activation Drives EV-A71-Induced Immune Dysregulation and Neural Injury in Severe HFMD
PRJNA1299456 | ENA
GenomicsMulti-omics based dynamic molecular changes characterization in EV-A71-infected mice elucidating potential therapeutic targets
Multi-omics based dynamic molecular changes characterization in EV-A71-infected mice elucidating potential therapeutic targets
PRJNA1062704 | ENA
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