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UnknownGSK137, a potent small-molecule BCL6 inhibitor with in vivo activity, suppresses antibody responses in mice.
Not available
S-EPMC8350397 | biostudies-literature
TranscriptomicsHost lung gene expression patterns predict the etiology of infectious pneumonias
Rationale: Lower respiratory tract infections continue to exact unacceptable worldwide mortality, often because the infecting pathogen cannot be identified. The respiratory epithelia provide protection from pneumonias through organism-specific generation of antimicrobial products, offering potentia...
ORGANISM(S): Mus musculus 
2009-04-29 | E-GEOD-15869 | biostudies-arrayexpress
UnknownRole of nicotine dependence on the relationship between variants in the nicotinic receptor genes and risk of lung adenocarcinoma.
Not available
S-EPMC4169410 | biostudies-literature
TranscriptomicsGene expression in mouse lung homogenates treated with synthetic TLR ligands to induce resistance
Infectious pneumonias exact an unacceptable mortality burden worldwide. Efforts to protect populations from pneumonia have historically focused on antibiotic development and vaccine-enhanced adaptive immunity. However, we have recently reported that the lungs’ innate defenses can be therapeuticall...
ORGANISM(S): Mus musculus 
2011-05-01 | E-GEOD-28994 | biostudies-arrayexpress
TranscriptomicsGene expression in mouse lung epithelial cells treated with synthetic TLR ligands to induce resistance
Infectious pneumonias exact an unacceptable mortality burden worldwide. Efforts to protect populations from pneumonia have historically focused on antibiotic development and vaccine-enhanced adaptive immunity. However, we have recently reported that the lungs’ innate defenses can be therapeuticall...
ORGANISM(S): Mus musculus 
2011-01-27 | E-GEOD-26864 | biostudies-arrayexpress
GenomicsA master cistromic circuit governing hepatic fibrogenesis [ChIP-seq]
Liver fibrosis is a reversible wound-healing response to liver injury and hepatic stellate cells (HSCs) are central cellular players that mediate hepatic fibrogenesis. However, the molecular mechanisms that govern this process remain unclear. Here, we reveal a novel cistromic circuit in HSCs compris...
ORGANISM(S): Homo sapiens 
2013-04-29 | E-GEOD-38103 | biostudies-arrayexpress
UnknownTriptolide targets super-enhancer networks in pancreatic cancer cells and cancer-associated fibroblasts.
Not available
S-EPMC7653036 | biostudies-literature
TranscriptomicsA master cistromic circuit governing hepatic fibrogenesis [expression array]
Liver fibrosis is a reversible wound-healing response to liver injury and hepatic stellate cells (HSCs) are central cellular players that mediate hepatic fibrogenesis. However, the molecular mechanisms that govern this process remain unclear. Expression profiling was used to explore the potential im...
ORGANISM(S): Rattus norvegicus 
2013-04-29 | E-GEOD-41579 | biostudies-arrayexpress
UnknownClinical and Genetic Risk Factors for Acute Pancreatitis in Patients With Acute Lymphoblastic Leukemia.
Not available
S-EPMC4962704 | biostudies-literature
UnknownSynthetic Lethal Screen Demonstrates That a JAK2 Inhibitor Suppresses a BCL6-dependent IL10RA/JAK2/STAT3 Pathway in High Grade B-cell Lymphoma.
Not available
S-EPMC4974382 | biostudies-literature
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