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GenomicsIntegrative genomic analysis of CREB defines a critical role for transcription factor networks in mediating the fed/fasted switch in liver
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-05-01 | E-GEOD-45733 | biostudies-arrayexpress
GenomicsMetabolic Transcription Factors Mediate Conserved Functions Largely via Species-Specific Binding Regions
The winged helix protein FOXA2 and the nuclear receptor PPARg are highly conserved, regionally-expressed transcription factors that regulate networks of genes controlling complex metabolic functions. Cistrome analysis for FOXA2 in mouse liver and PPARg in mouse adipocytes has previously produced co...
ORGANISM(S): Homo sapiens 
2011-04-06 | E-GEOD-25836 | biostudies-arrayexpress
TranscriptomicsHistone Deacetylase 3 is an Epigenomic Brake in Macropahge Alternative Activation
This SuperSeries is composed of the following subset Series: GSE33596: Histone Deacetylase 3 is an Epigenomic Brake in Macrophage Alternative Activation (ChIP-Seq) GSE33608: Histone Deacetylase 3 is an Epigenomic Brake in Macrophage Alternative Activation (microarray) Refer to individual Series
ORGANISM(S): Mus musculus 
2011-11-10 | E-GEOD-33609 | biostudies-arrayexpress
GenomicsEnhanceBeta TCPA - Enhancer marks in sorted islet cells
Performed ChIP-seq for H3K27ac and H3K4me1 in purified (FACS sorted) islet alpha and beta cell populations. These ChIP-seq experiments can be used to identify cell-type-specific enhancers.
ORGANISM(S): Homo sapiens 
2015-02-26 | E-MTAB-3411 | biostudies-arrayexpress
TranscriptomicsCircadian Enhancers Coordinate Multiple Phases of Rhythmic Gene Transcription In Vivo
Mammalian transcriptomes display complex circadian rhythms with multiple phases of gene expression that cannot be accounted for by current models of the molecular clock.  We have determined the underlying mechanisms by measuring nascent RNA transcription around the clock in mouse liver. Unbiased ex...
ORGANISM(S): Mus musculus 
2015-01-06 | E-GEOD-59460 | biostudies-arrayexpress
GenomicsHistone Deacetylase 3 is an Epigenomic Brake in Macrophage Alternative Activation (ChIP-Seq)
We report the genomic regions enriched in Histone Deacetylase 3 (HDAC3) in mouse bone marrow derived macrophages. Furthermore, we also report the genomic acetylation pattern on Histone 3, Lysine 9 (H3K9) in macrophages with and without HDAC3 and/or treated with Th2 cytokine IL-4. HDAC3 enriched gen...
ORGANISM(S): Mus musculus 
2011-11-10 | E-GEOD-33596 | biostudies-arrayexpress
GenomicsIntegrative genomic analysis of CREB defines a critical role for transcription factor networks in mediating the fed/fasted switch in liver [ChIP-seq]
Metabolic homeostasis in mammals critically depends on the regulation of fasting-induced genes by CREB in the liver. Previous genome-wide analysis has shown that only a small percentage of CREB target genes are induced in response to fasting-associated signaling pathways. The precise molecular mecha...
ORGANISM(S): Mus musculus 
2013-05-01 | E-GEOD-45674 | biostudies-arrayexpress
TranscriptomicsCircadian Enhancers Coordinate Multiple Phases of Rhythmic Gene Transcription In Vivo
Mammalian transcriptomes display complex circadian rhythms with multiple phases of gene expression that cannot be accounted for by current models of the molecular clock.M-BM- We have determined the underlyingM-BM- mechanisms by measuring nascent RNA transcription around the clock in mouse liver. U...
ORGANISM(S): Mus musculus 
2014-11-21 | E-GEOD-59486 | biostudies-arrayexpress
TranscriptomicsEpigenomic plasticity enables human pancreatic alpha to beta cell reprogramming
Insulin-secreting β cells and glucagon-secreting α cells maintain physiological blood glucose levels, and their malfunction drives diabetes development. Using ChIP sequencing and RNA sequencing analysis, we determined the epigenetic and transcriptional landscape of human pancreatic α, β, and exocrin...
ORGANISM(S): Homo sapiens 
2013-08-28 | E-GEOD-50386 | biostudies-arrayexpress
TranscriptomicsIntegrative genomic analysis of CREB defines a critical role for transcription factor networks in mediating the fed/fasted switch in liver [array]
Metabolic homeostasis in mammals critically depends on the regulation of fasting-induced genes by CREB in the liver. Previous genome-wide analysis has shown that only a small percentage of CREB target genes are induced in response to fasting-associated signaling pathways. The precise molecular mecha...
ORGANISM(S): Mus musculus 
2013-05-01 | E-GEOD-45731 | biostudies-arrayexpress
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