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ProteomicsMulti-omics analysis of β-catenin oncogenic networks
We used interaction and expression proteomic techniques in conjunction with RNA-Seq transcriptomic analysis to analyse how a β-catenin stabilizing mutation alters molecular networks in colorectal cancer cells. Integrated computational analyses of allowed us to identify significantly altered sub-netw...
ORGANISM(S): Homo sapiens (Human) 
2018-05-18 | PXD006053 | Pride
Human Hct116 Colorectal cancer 
ProteomicsDeep proteomic analysis of Dnmt1 mutant/hypomorphic colorectal cancer cells reveals dys-regulation of Epithelial-Mesenchymal Transition and subcellular re-localization of Beta-Catenin
DNA methyltransferase I plays the central role in maintenance of CpG DNA methylation patterns across the genome and alteration of CpG methylation patterns is a frequent and significant occurrence across many cancers. Cancer cells carrying hypomorphic alleles of Dnmt1 have become important tools for ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD014632 | Pride
Dnmt1  methltransferase  hct116  colorectal cancer 
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