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TranscriptomicsDNMT1 Maintains Progenitor Function in Self-Renewing Somatic Tissue
Progenitor cells maintain self-renewing tissues throughout life by sustaining their capacity for proliferation while suppressing cell cycle exit and terminal differentiation. DNA methylation provides a potential epigenetic mechanism for the cellular memory needed to preserve the somatic progenitor s...
ORGANISM(S): Homo sapiens 
2010-06-23 | E-GEOD-18590 | biostudies-arrayexpress
GenomicsThe DAXX co-repressor is directly recruited to active regulatory elements genome-wide to regulate autophagy programs in a model of human prostate cancer (ChIP-seq)
This study was aimed at understanding the genome-wide binding and regulatory role of the DAXX transcriptional repressor, recently implicated in PCa. ChIP-Seq analysis of genome-wide distribution of DAXX in PC3 cells revealed over 59,000 DAXX binding sites, found at regulatory enhancers and promoters...
ORGANISM(S): Homo sapiens 
2015-06-24 | E-GEOD-68647 | biostudies-arrayexpress
TranscriptomicsExpression data of Dnmt1 haploinsufficient leukemia stem cells and bulk leukemia
Leukemia stem cells (LSCs) are an attractive target in treatment of many types of blood cancers. There remains an incomplete understanding of the epigenetic mechanisms driving LSC formation and maintenance, and how this compares to the epigenetic regulation of normal hematopoietic stem cells (HSCs)....
ORGANISM(S): Mus musculus 
2012-03-14 | E-GEOD-31626 | biostudies-arrayexpress
TranscriptomicsRNA sequencing (RNA-SEQ) of Dnmt1 and Dnmt3a conditional knockout mice
Purpose: Epigenetic regulation contributes to pathogenesis of neurondegenerative disease. We found that dis-regulation of a 242-gene subnetwork related to DNA methylation regulated neuronal differentiation are common in AD and HD. There are two DNA methyltransferases, DNMT1 and DNMT3A, in the subn...
ORGANISM(S): Mus musculus 
2014-07-31 | E-GEOD-58261 | biostudies-arrayexpress
TranscriptomicsRIPSEQ DNMT1 HL60
Identification of the all RNA species associated with DNMT1. Using a comparative genome-scale approach we identified and correlated the RNA species physically associated with DNMT1 and proximal to the annotated genes to the methylation status of the corresponding loci and expression levels of the re...
ORGANISM(S): Homo sapiens 
2012-12-01 | E-GEOD-32162 | biostudies-arrayexpress
ProteomicsInhibition of DNMT1 methyltransferase activity via glucose-regulated O-GlcNAcylation alters the epigenome
The DNA methyltransferase activity of DNMT1 is vital for genomic maintenance of DNA methylation. We report here that DNMT1 function is regulated by O-GlcNAcylation, a protein modification that is sensitive to glucose levels, and that elevated O-GlcNAcylation of DNMT1 from high glucose environment le...
ORGANISM(S): Homo sapiens (Human) 
2023-07-26 | PXD043031 | Pride
Metabolism O-glcnacylation Epigenetics Hyperglycemia 
ProteomicsDNMT1 IP-MS alalysis to identify ubiquitin-dependent interacting partners
Stable inheritance of DNA methylation is critical for maintaining the differentiated phenotypes in multicellular organisms. However, the molecular basis ensuring high fidelity of maintenance DNA methylation is largely unknown. Here, we demonstrate that two distinct modes of DNMT1 recruitment, one is...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2020-02-25 | PXD015282 | Pride
Dnmt1 ubiquitin 
TranscriptomicsGenome wide expression analysis in AtT-20 cells following Dnmt1 knockdown
Efficient and sustained knockdown of DNMT1 transcript and protein was achieved using a consecutive transfection protocol in the mouse pituitary adenoma cell line, AtT-20. Genome wide microarray analysis identified 91 transcripts that were significantly differentially expressed relative to cells tre...
ORGANISM(S): Mus musculus 
2008-12-30 | E-GEOD-10552 | biostudies-arrayexpress
ProteomicsDnmt1 has de novo activity targeted to transposable elements
DNA methylation plays a critical role in development, particularly in repressing retrotransposons. The mammalian methylation landscape is dependent on the combined activities of the canonical maintenance enzyme Dnmt1 and the de novo Dnmts, 3a and 3b. Here we demonstrate that Dnmt1 displays de nov...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-29 | PXD025736 | Pride
Dnmt1 Uhrf1 Retrotransposon Dna methylation 
ProteomicsDeep proteomic analysis of Dnmt1 mutant/hypomorphic colorectal cancer cells reveals dys-regulation of Epithelial-Mesenchymal Transition and subcellular re-localization of Beta-Catenin
DNA methyltransferase I plays the central role in maintenance of CpG DNA methylation patterns across the genome and alteration of CpG methylation patterns is a frequent and significant occurrence across many cancers. Cancer cells carrying hypomorphic alleles of Dnmt1 have become important tools for ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD014632 | Pride
Dnmt1  methltransferase  hct116  colorectal cancer 
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