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GenomicsRebalancing the brain: The therapeutic potential of false neurotransmitters in excitatory-inhibitory imbalance
Rebalancing the brain: The therapeutic potential of false neurotransmitters in excitatory-inhibitory imbalance
PRJNA985658 | ENA
GenomicsThe imbalance of excitatory/inhibitory neuron differentiation in neurodevelopmental disorders with an NR2F1 point mutation
The imbalance of excitatory/inhibitory neuron differentiation in neurodevelopmental disorders with an NR2F1 point mutation
PRJNA549592 | ENA
GenomicsThe imbalance of excitatory/inhibitory neuron differentiation in neurodevelopmental disorders with an NR2F1 point mutation (The Third Replicate)
The imbalance of excitatory/inhibitory neuron differentiation in neurodevelopmental disorders with an NR2F1 point mutation (The Third Replicate)
PRJNA593572 | ENA
ProteomicsHuman NMDAR autoantibodies disrupt excitatory-inhibitory balance leading to hippocampal network hypersynchrony
Specific autoantibodies against the NMDA-receptor (NMDAR) GluN1 subunit cause severe and debilitating NMDAR-encephalitis. Autoantibodies induce prototypic disease symptoms resembling schizophrenia, including psychosis and cognitive dysfunction. Using a mouse passive transfer model applying human mon...
ORGANISM(S): Mus musculus (Mouse) 
2023-09-24 | PXD032055 | Pride
Network oscillation Excitatory-inhibitory imbalance Autoantibodies Nmda receptor encephalitis Nmda receptor Theta-gamma coupling Neural network modeling 
TranscriptomicsRebalancing the brain: The therapeutic potential of false neurotransmitters in excitatory-inhibitory imbalance
Excitatory-inhibitory (E-I) balance results from a complex interplay between glutamatergic and GABAergic neurons, and E-I imbalance has been proposed to contribute to many neurological diseases. We have created the first excitatory (S-2-methyglutamate or S-2MeGlu) and inhibitory (R-4-aminopentanoate...
ORGANISM(S): Mus musculus 
2026-04-01 | GSE235285 | GEO
TranscriptomicsThe imbalance of excitatory/inhibitory neuron differentiation in neurodevelopmental disorders with an NR2F1 point mutation
Recent studies have revealed an essential role for embryonic cortical development in the pathophysiology of neurodevelopmental disorders, including autism spectrum disorder (ASD). However, the genetic basis and underlying mechanisms remain unclear. Here, we generate mutant human embryonic stem cell ...
ORGANISM(S): Homo sapiens 
2020-04-21 | GSE132965 | GEO
TranscriptomicsThe imbalance of excitatory/inhibitory neuron differentiation in neurodevelopmental disorders with an NR2F1 point mutation (The Third Replicate)
Recent studies have revealed an essential role for embryonic cortical development in the pathophysiology of neurodevelopmental disorders, including autism spectrum disorder (ASD). However, the genetic basis and underlying mechanisms remain unclear. Here, we generate mutant human embryonic stem cell ...
ORGANISM(S): Homo sapiens 
2023-04-07 | GSE141468 | GEO
UnknownDistinct manifestations of excitatory-inhibitory imbalance associated with amyloid-β and tau in patients with Alzheimer's disease.
Not available
S-EPMC12381375 | biostudies-literature
UnknownSeizures exacerbate excitatory: inhibitory imbalance in Alzheimer's disease and 5XFAD mice.
Not available
S-EPMC11146435 | biostudies-literature
UnknownTau pathology reprograms glucose metabolism to support cortical hyperexcitability, excitatory/inhibitory imbalance, and sleep loss.
Not available
S-EPMC12830363 | biostudies-literature
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