Sort   by:  
 Page size 
MetabolomicsHuman gut bacteria increase PFNA excretion in vivo

Per- and polyfluoroalkyl Substances (PFAS) – the so-called ‘forever chemicals’ – are a major cause of environmental and health concern due to their toxicity and long-term persistence. Yet, no efficient mechanisms for their removal have been identified. Here we report the potential of human gut ba...

2025-06-30 | MTBLS10636 | MetaboLights
MetabolomicsLimosilactobacillus fermentum-derived 4-guanidinobutyric acid promotes intestinal urate excretion via the HNF4α-ABCG2 axis to alleviate hyperuricemia

Hyperuricemia is a prevalent metabolic illness and an established risk factor for gout and chronic renal disease. Present urate-lowering medications are often limited by side effects, highlighting the necessity for innovative strategies. The gut microbiota has a role in urate homeostasis; however...

2026-01-26 | MTBLS13637 | MetaboLights
ProteomicsBiliary excretion of excess iron in mice
Iron is an essential nutrient yet toxic in excess. Our understanding of mammalian mechanisms of dietary iron absorption exceeds our understanding of mechanisms of iron excretion. Here we demonstrate that biliary excretion of excess iron in mice requires the metal transporter SLC39A14 and that excess...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2021-02-10 | MSV000086836 | MassIVE
ModelsKraan199_Kinetics of Cortisol Metabolism and Excretion.
A new model is proposed to study the kinetics of [3H]cortisol metabolism by using urinary data only. The model consists of 5 pools, in which changes of the fractions of dose are given by a system of 5 ordinary differential equations. After i.v. administration of [3H]cortisol to 8 multiple pituitary ...
2024-09-02 | BIOMD0000000916 | BioModels
TranscriptomicsSupplementary dietary calcium stimulates faecal fat and bile acid excretion, but does not protect against obesity and insulin resistance in C57BL/6J mice
There is increased interest in the potential protective role of dietary Ca in the development of metabolic disorders related to the metabolic syndrome. Ca-induced intestinal precipitation of fatty acids and bile acids as well as systemic metabolic effects of Ca on adipose tissue is proposed to play ...
ORGANISM(S): Mus musculus 
2011-03-03 | E-GEOD-18581 | biostudies-arrayexpress
TranscriptomicsSaturated fat diet induces transintestinal cholesterol excretion in mice
Intake and absorption of cholesterol (the latter determined by double labeled cholesterol methodology) were nearly unchanged in mice fed the saturated fat diet, but the fecal excretion of neutral sterols (i.e. cholesterol and its microbial conversion products) was increased compared with control die...
ORGANISM(S): Mus musculus 
2021-02-01 | GSE37097 | GEO
ProteomicsCharacterization of Naegleria fowleri from two human cases: insights into its excretion/secretion products
Characterization of Naegleria fowleri from two human cases: insights into its excretion/secretion products
ORGANISM(S): Naegleria Fowleri (ncbitaxon:5763) 
2025-04-30 | MSV000097773 | MassIVE
ProteomicsProteomic analyses of urinary exosomes identify heparanase, cathepsin C, 2-macroglobulin and sarcoplasmic endoplasmic Ca2+ ATPase-3 (SERCA3) as potential biomarkers for early diagnosis of sickle nephropathy
Sickle cell disease-induced nephropathy (SCN) is a leading cause of morbidity and mortality in sickle cell disease (SCD). Early intervention is crucial for mitigating its effects. However, current diagnostic methods rely on non-specific tests and may not detect SCN until renal damage has become irre...
ORGANISM(S): Mus Musculus (mouse) 
2024-02-07 | PXD043401 | JPOST Repository
ProteomicsSLC17 transporters mediate renal excretion of Lac-Phe in mice and humans
N-lactoyl-phenylalanine (Lac-Phe) is a lactate-derived metabolite that suppresses food intake and body weight. Little is known about the mechanisms that mediate Lac-Phe transport across cell membranes. Here we identify SLC17A1 and SLC17A3, two kidney-restricted plasma membrane-localized solute carri...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-17 | PXD054202 | Pride
Kidney Lac-phe Transporter Urine 
ProteomicsSLC17 transporters mediate renal excretion of Lac-Phe in mice and humans
N-lactoyl-phenylalanine (Lac-Phe) is a lactate-derived metabolite that suppresses food intake and body weight. Little is known about the mechanisms that mediate Lac-Phe transport across cell membranes. Here we identify SLC17A1 and SLC17A3, two kidney-restricted plasma membrane-localized solute carri...
ORGANISM(S): Mus musculus (Mouse) 
2025-01-18 | PXD054049 | Pride
Slc17 Lac-phe Transporter 
Sort   by:  
 Page size