Sort   by:  
 Page size 
ProteomicsSLC17 transporters mediate renal excretion of Lac-Phe in mice and humans
N-lactoyl-phenylalanine (Lac-Phe) is a lactate-derived metabolite that suppresses food intake and body weight. Little is known about the mechanisms that mediate Lac-Phe transport across cell membranes. Here we identify SLC17A1 and SLC17A3, two kidney-restricted plasma membrane-localized solute carri...
ORGANISM(S): Mus musculus (Mouse) 
2025-01-18 | PXD054049 | Pride
Slc17 Lac-phe Transporter 
ProteomicsSLC17 transporters mediate renal excretion of Lac-Phe in mice and humans
N-lactoyl-phenylalanine (Lac-Phe) is a lactate-derived metabolite that suppresses food intake and body weight. Little is known about the mechanisms that mediate Lac-Phe transport across cell membranes. Here we identify SLC17A1 and SLC17A3, two kidney-restricted plasma membrane-localized solute carri...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-17 | PXD054202 | Pride
Kidney Lac-phe Transporter Urine 
UnknownLac-Phe mediates the anti-obesity effect of metformin.
Not available
S-EPMC10635077 | biostudies-literature
UnknownSLC17A1/3 transporters mediate renal excretion of Lac-Phe in mice and humans.
Not available
S-EPMC11319466 | biostudies-literature
UnknownMetformin and feeding increase levels of the appetite-suppressing metabolite Lac-Phe in humans.
Not available
S-EPMC11052712 | biostudies-literature
UnknownThe anti-obesogenic metabolite, Lac-Phe, is elevated by metformin treatment in prostate cancer patients
Not available
S-SCDT-10_1038-S44321-026-00408-6 | biostudies-other
TranscriptomicsMetformin inhibits mitochondrial complex I in intestinal epithelium to promote glycemic control
Metformin is a therapeutically versatile biguanide drug primarily prescribed for type II diabetes. Despite its extensive use, the mechanisms underlying many of its clinical effects, including attenuated postprandial glucose excursions, elevated intestinal glucose uptake, and increased production of ...
ORGANISM(S): Mus musculus 
2025-12-04 | GSE293164 | GEO
UnknownExercise-induced Metabolite N-lactoyl-phenylalanine Ameliorates Colitis by Inhibiting M1 Macrophage Polarization via the Suppression of the NF-κB Signaling Pathway.
Not available
S-EPMC12391280 | biostudies-literature
UnknownN-Lactoyl Phenylalanine Disrupts Insulin Signaling, Induces Inflammation, and Impairs Mitochondrial Respiration in Cell Models.
Not available
S-EPMC12384308 | biostudies-literature
UnknownExercise-Induced N-Lactoylphenylalanine Predicts Adipose Tissue Loss during Endurance Training in Overweight and Obese Humans.
Not available
S-EPMC9863672 | biostudies-literature
Sort   by:  
 Page size