Sort   by:  
 Page size 
ProteomicsDetermining changes in the oxidized proteome of human CD8+ T cells with enhancing proteasome activity
Chronic T cell receptor (TCR) stimulation, combined with adverse conditions in the tumor microenvironment (TME) such as hypoxia and nutrient deprivation, frequently results in T cell exhaustion. Exhausted T cells (TEX) experience oxidative stress, which causes an accumulation of oxidized proteins wi...
ORGANISM(S): Homo sapiens (Human) 
2026-03-12 | PXD070152 | Pride
Exhausted t cells (tex) Oxidative stress Proteasome 
TranscriptomicsscRNA-seq characterisation of in vitro-generated CD8+ exhausted human T cells
scRNA-seq was performed to characterise an in vitro model of T cell exhaustion. CD8+ T cells from two donors underwent chronic stimulation to induce exhaustion and samples were collected from multiple points across the protocol to examine the subsets and transcriptional signatures present.
ORGANISM(S): Homo sapiens 
2026-05-31 | E-MTAB-15435 | biostudies-arrayexpress
GenomicsRNA sequencing of human CD8+ T cell subsets [TEX]
RNA sequencing of human CD8+ T cell subsets [TEX]
PRJNA980108 | ENA
ProteomicsThe Prostacyclin Receptor is a NRF2-regulated Immune Checkpoint in CD8 T cells
Immune checkpoint inhibitor (ICI) therapies revitalize anti-cancer responses by intercepting protein-protein interactions between exhausted CD8 T (Tex) cells and cancer cells (e.g. PD-1:PD-L1). However, up to 50% of patients receiving ICIs relapse, warranting further interrogation of the underpinnin...
ORGANISM(S): Mus musculus (Mouse) 
2025-04-25 | PXD052688 | Pride
Adoptive cell therapy T cell exhaustion Immune checkpoint 
ProteomicsProteostasis sustains T cell differentiation potential and tumor-infiltrating lymphocyte function
Tumors that contain tumor-infiltrating lymphocytes (TIL) with tissue-resident memory T cells (TRM) features are associated with better patient prognoses. While CD8+ T cells that target tumors often fail to restrain tumor growth due to progressive T cell exhaustion, pathogen-specific TRM survey tissu...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-21 | PXD070932 | Pride
Dia-pasef Low input proteomics T cells 
GenomicsTumor-specific memory-like progenitor exhausted CD8+ T cell subsets diverge into terminally exhausted cells and long-lived memory T cells
Tumor-specific memory-like progenitor exhausted CD8+ T cell subsets diverge into terminally exhausted cells and long-lived memory T cells
PRJNA1491478 | ENA
GenomicsEpigenetic characterization of T progenitor exhausted and terminally exhausted T cells in chronic infection [ATACseq_Prdm1YFP]
Exhausted T cells are a heterogeneous population of antigen-reactive CD8+ T cells elicited by chronic antigen exposure. T progenitor exhausted (TPEX) and terminally exhausted (TEX) cells exhibit distinct gene expression profiles, but how their chromatin accessibility profiles differ remains incomple...
ORGANISM(S): Mus musculus 
2025-10-02 | GSE294878 | GEO
UnknownAntigen reactivity defines tissue-resident memory and exhausted T cells in tumors.
Not available
S-EPMC12764432 | biostudies-literature
UnknownEpigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation.
Not available
S-EPMC8323971 | biostudies-literature
GenomicsAntigen reactivity defines tissue-resident memory and exhausted T cells in tumours
Antigen reactivity defines tissue-resident memory and exhausted T cells in tumours
PRJNA1336097 | ENA
Sort   by:  
 Page size