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MetabolomicsComparative Analysis of Host Metabolic Alterations in Murine Malaria Models with Uncomplicated or Severe Malaria

Malaria varies in severity, with complications ranging from uncomplicated to severe malaria. Severe malaria could be attributed to peripheral hyperparasitemia or cerebral malaria. The metabolic interactions between the host and Plasmodium species are yet to be understood during these inf...

2022-09-14 | MTBLS4387 | MetaboLights
TranscriptomicsRNA-seq analysis of anti-malarial drug chemotherapy of murine experimental Cerebral Malaria (ECM)
Cerebral Malaria (HCM) is a serious neurological complication caused by Plasmodium falciparum infection. Currently the only treatment for HCM is the provision of anti-malarial drugs; however, such treatment by itself often fails to prevent death or development of neurological sequelae. To identify n...
ORGANISM(S): Mus musculus 
2018-07-03 | E-MTAB-6474 | biostudies-arrayexpress
TranscriptomicsCommon Irf-regulated genomic responses drive pathological inflammation during experimental cerebral malaria as well as protective response against M. tuberculosis
Analysis of transcriptional response to Plasmodium berghei ANKA infection in cerebral malaria susceptible C57BL/6 mouse brains as well as cerebral malaria resistant BXH2 mice which carry a severe hypomorphic Irf8-R294C allele. Interferon Regulatory Factor 8 (IRF8) is required for development, matura...
ORGANISM(S): Mus musculus 
2015-01-16 | E-GEOD-65036 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse cerebral malaria susceptible and resistant animals
Cerebral malaria (CM) is a leading cause of death in the world. Better understanding of the pathogenesis of this disease is critical for the development of novel therapies. In this work, we investigated temporal gene expression profiles in the brains of CM-susceptible and CM-resistant mice during in...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7814 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of genetically cerebral malaria-resistant (CM-R) and cerebral malaria-susceptible (CM-S) mouse strains
Gene expression patterns were investigated in well-defined genetically cerebral malaria-resistant (CM-R) and cerebral malaria-susceptible (CM-S) mouse strains. cDNA microarrays were used to search for differentially expressed genes in mouse brain. Four mouse strains, known to differ in susceptibilit...
ORGANISM(S): Mus musculus 
2005-06-30 | E-MEXP-370 | biostudies-arrayexpress
TranscriptomicsAcute Lung Injury In Experimental Malaria
Although respiratory distress is a common complication of severe malaria, little is known about the underlying molecular basis of lung dysfunction. Animal models have provided powerful insights into the pathogenesis of severe malaria syndromes such as cerebral malaria; however, no model of malaria-i...
ORGANISM(S): Mus musculus 
2010-05-26 | E-GEOD-9497 | biostudies-arrayexpress
ProteomicsCharacterisation of the protein cargo of murine plasma microparticles released during experimental cerebral malaria
Cerebral malaria (CM) is a severe complication of a Plasmodium falciparum infection and is still responsible for a high number of deaths and long term disabilities in children in sub-Saharan Africa. The pathogenesis of this syndrome remains incompletely understood but a number of mechanisms and effe...
ORGANISM(S): Mus musculus (Mouse) 
2016-12-13 | PXD003772 | Pride
Qexactive orbitrap Protein cargo Tandem mass tag (tmt) Microparticles Experimental cerebral malaria 
TranscriptomicsInfection-induced resistance to experimental cerebral malaria
Cerebral malaria (CM) is one of the most severe complications of malaria infection. There is evidence that repeated parasite exposure promotes resistance against CM, as indicated by the low incidence of CM in adults in malaria-endemic regions. However, the immunological basis of this infection-induc...
ORGANISM(S): Mus musculus 
2019-02-19 | E-MTAB-5513 | biostudies-arrayexpress
TranscriptomicsPredominance of interferon-related responses in the brain during murine malaria as identified by microarray analysis.
Cerebral malaria (CM) can be a fatal manifestation of Plasmodium falciparum infection. We examined global gene expression patterns by microarray during fatal murine CM (FMCM) and non-cerebral malaria (NCM). There was differential expression of a number of genes, including some not yet characterized ...
ORGANISM(S): Mus musculus 
2008-03-14 | E-GEOD-9808 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of brain tissue from cerebral malaria-resistant and susceptible strains of mice in a time series following infection with Plasmodium berghei
Microarray analyses allow the identification and assessment of molecular signatures in whole tissues undergoing pathological processes. To better understand cerebral malaria pathogenesis, we investigated intra-cerebral gene-expression profiles in well-defined genetically cerebral malaria-resistant (...
ORGANISM(S): Mus musculus 
2007-05-01 | E-MEXP-1018 | biostudies-arrayexpress
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