Sort   by:  
 Page size 
MetabolomicsGut microbiota within-host evolution enforces colonization resistance against enteric infection

Limited resource availability in the gut promotes competitive interactions between bacteria, which drive adaptive within-host evolution. While the role of bacterial adaptive evolution of bacterial communities has been extensively studied, its functional implications for host physiology remain unk...

2026-08-03 | MTBLS10327 | MetaboLights
MetabolomicsAdaptive Evolution Reveals Mechanisms of Isobutanol Tolerance in Zymomonas mobilis

Isobutanol production has been demonstrated in E. coli and Z. mobilis using heterologous pathways, with titers reaching up to 60% of the theoretical yield under optimized conditions. However, these results often depend on impractical setups, such as continuous product extraction, oxygenation, or ...

2026-03-18 | MTBLS14081 | MetaboLights
MetabolomicsHarnessing a Germ-Free Mouse Gut Bioreactor for Directed Evolution of Probiotics to Combat NAFLD

The data uploaded in this study were obtained from an interventional experiment in which non-alcoholic fatty liver disease (NAFLD) model mice were treated with either the original or adapted bacterial strains, followed by fecal sample collection and targeted bile acid metabolomic analysis.

2026-01-20 | MTBLS13718 | MetaboLights
TranscriptomicsExploiting Temporal Collateral Sensitivity in Tumor Clonal Evolution
In this study, using a murine model of Ph+ acute lymphoblastic leukemia (Ph+ ALL), a combined pharmacological profile and drug selection experimental approach identified distinct stages of tumor clonal evolution with vulnerabilities to sets of small molecules. Through genotypic, phenotypic, signalin...
ORGANISM(S): Mus musculus 
2016-04-05 | E-GEOD-72910 | biostudies-arrayexpress
GenomicsTribolium castaneum experimental evolution
Tribolium castaneum experimental evolution
PRJNA552902 | ENA
GenomicsExperimental Chlorovirus evolution
Strong selection and high mutation supply characterize experimental Chlorovirus evolution
PRJEB46915 | ENA
ProteomicsProteome evolution under essential resource limitation
Resource limitation is a major driver of ecological and evolutionary dynamics of organisms. Short-term responses to resource limitation include plastic changes in molecular phenotypes including protein expression. Yet little is known about the evolution of the molecular phenotype under longer-term r...
ORGANISM(S): Chlamydomonas reinhardtii 
2018-11-08 | PXD010847 | Pride
Molecular phenotype Divergent evolution Shotgun proteomics Convergent evolution Mudpit Chlamydomonas reinhardtii Resource limitation Stress Selection 
TranscriptomicsBP001-002: The genomic landscape of compensatory evolution
Adaptive evolution is generally assumed to progress through the accumulation of beneficial mutations. However, deleterious mutations may also have an important role by promoting adaptive genetic changes that are otherwise inaccessible. Here we study the capacity of the bakerM-bM-^@M-^Ys yeast genome...
ORGANISM(S): Saccharomyces cerevisiae BY4741 
2014-08-27 | E-GEOD-55373 | biostudies-arrayexpress
GenomicsGenomic evolution of experimental Chlorovirus evolution
Strong selection and high mutation supply characterize experimental Chlorovirus evolution
PRJEB45939 | ENA
TranscriptomicsEvolution and dynamics of small RNA response to a retroelement invasion in Drosphila
Although small RNAs efficiently control transposition activity of most transposons in the host genome, such immune system is not always applicable against new transposon's invasions. Here we explored a possibility to introduce potentially mobile copy of the Penelope retroelement previously implicate...
ORGANISM(S): Drosophila melanogaster 
2012-10-31 | E-GEOD-41953 | biostudies-arrayexpress
Sort   by:  
 Page size