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TranscriptomicsExtracellular Matrix Formation Enhances the Ability of Streptococcus pneumoniae to Cause Invasive Disease
Background. During infection, pneumococci exist mainly in sessile biofilms rather than in planktonic form, except during sepsis. However, relatively little is known about how biofilms contribute to pneumococcal pathogenesis. Methods. We performed a biofilm assay and mouse infection experiments on op...
ORGANISM(S): Streptococcus pneumoniae 
2011-04-20 | E-BUGS-117 | biostudies-arrayexpress
MetabolomicsThe Impacts of Sortase A and the 4'-Phosphopantetheinyl Transferase Homolog Sfp on Streptococcus mutans Extracellular Membrane Vesicle Biogenesis

Extracellular membrane vesicles (EMVs) are produced by many Gram-positive organisms, but information regarding vesiculogenesis is incomplete. We used single gene deletions to evaluate the impacts on Streptococcus mutans EMV biogenesis of Sortase A (SrtA), which affects S. mutans...

2021-10-06 | MTBLS1812 | MetaboLights
OtherExtracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.
Data from MASSIVE, MSV000078555. Experiment: D120204_CoN_2207, file: D120204_MGH_2207_OGE07_rafkt_ft8dt_cc_01.mzml. Published as part of BMC Cancer. 2014 Jul 18;14(1):518 . From the Abstract: {{i}} We have used enrichment of extracellular matrix (ECM) from human patient samples and proteomics to de...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32310002460 | GPMDB
Resource Reanalysis 
ProteomicsProtein composition of the extracellular matrix in idiopathic germ cell aplasia
The somatic microenvironment supports spermatogonial stem cell differentiation into sperm. Extracellular matrix (ECM) plays multiple roles in the stem cell niche, including self-renewal, proliferation, differentiation and survival of spermatogonial cells. The pathophysiology of male infertility mig...
ORGANISM(S): Homo sapiens (Human) 
2019-01-07 | PXD011817 | Pride
Extracellular matrix  male infertility  label-free quantitative proteomics 
ProteomicsProteomic profiling of human left ventricular extracellular matrix
Proteomic analysis of decellularized human left ventricular extracellular matrix used for engineering humanized heart tissues. Data were generated to characterize ECM composition supporting cardiotoxicity assessment in a recellularized engineered heart tissue platform.
ORGANISM(S): Homo sapiens (Human) 
2026-04-27 | PXD074354 | Pride
Heart Ventricular Extracellular matrix 
TranscriptomicsTranscription profiling of Zebrafish regenerating caudal fin tissue in the presence and absence of the dioxin TCDD
Adult zebrafish can completely regenerate their caudal fin following amputation. This complex process is initiated by the formation of an epithelial would cap over the amputation site by 12 hours post amputation (hpa). Once the cap is formed, mesenchymal cells proliferate and migrate from sites dist...
ORGANISM(S): Danio rerio 
2007-10-05 | E-GEOD-3667 | biostudies-arrayexpress
ProteomicsProteomic analysis of extracellular matrix remodeling during zebrafish heart regeneration
Adult zebrafish, in contrast to mammals, are able to regenerate their hearts in response to injury or experimental amputation. Our understanding of the cellular and molecular bases that underlie this process, although fragmentary, has increased significantly over the last years. However, the role of...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2019-08-26 | PXD010092 | Pride
Extracellular matrix  heart regeneration 
OtherExtracellular matrix signatures of human mammary carcinoma identify novel metastasis promoters.
Data from Massive, MSV000078535. MDAMB23 experiment: D101003_MDAMB231_1_OGE, file: D101003_MDAMB231_1_OGE02_rafkt_ft8_cc_01.mzml. Published as part of Elife. 2014 Mar 11;3:e01308 . From the Abstract: {{i}} In this study, we use proteomics to investigate the ECM of human mammary carcinoma xenografts...
ORGANISM(S): Homo_sapiens_viruses,mus_musculus_viruses, Human_female,mouse_female 
GPM32320002348 | GPMDB
Resource Reanalysis 
ProteomicsLC-MS/MS of Versatile Decellularized Human Lung Extracellular Matrix-Derived Hydrogels
Decellularized ECM (dECM) hydrogels derived from human lungs can provide valuable insight into patient-specific and lung pathophysiology. Herein, we present the approach and some initial results that highlight the unique characteristics of this dECM hydrogel platform and its benefits for a variety o...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-11-22 | MSV000090771 | MassIVE
ProteomicsMustn1 is a smooth muscle cell-secreted micropeptide that modulates skeletal muscle extracellular matrix composition
We show that Mustn1 (Musculoskeletal embryonic nuclear protein 1, also known as Mustang) is highly expressed in skeletal muscle during the early stages of hindlimb reloading. Mustn1 expression is transiently elevated in mouse and human skeletal muscle in response to intense exercise, resistance exer...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-23 | PXD047169 | Pride
Skeletal muscle Extracellular matrix 
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