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ProteomicsOncogenic and microenvironmental signals drive cell type-specific apoptosis resistance in juvenile myelomonocytic leukemia
Juvenile myelomonocytic leukemia (JMML) is caused by constitutively activated RAS signalling and is characterized by increased proliferation and predominant myelomonocytic differentiation of hematopoietic cells. Using Mx-Cre;PTPN11D61Y mice, which reflect human JMML, we show that RAS pathway activat...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD055845 | Pride
Ptpn11 Bcl2 Jmml Apoptosis Bcl-xl Juvenile monocytic leukemia Mcl-1 Extrinsic and intrinsic shp2 signalling Shp2 
TranscriptomicsThe PRC1 protein RING1B contributes to Ewing sarcoma tumorigenesis by repressing the NaV1.6 sodium channel and modulating the NF-kB pathway, independently of the fusion oncoprotein.
Ewing sarcoma (ES) is an aggressive tumor molecularly defined by reciprocal translocations of EWSR1 to an ETS transcription factor. The functions of EZH2 and BMI1, two proteins of the Polycomb group (PcG) of epigenetic repressors, have been previously shown to mediate specific features in EWSR1/ETS-...
ORGANISM(S): Homo sapiens 
2016-06-30 | E-GEOD-71007 | biostudies-arrayexpress
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