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ProteomicsDiscovery and development of CLL-1 as a cellular immunotherapy target in juvenile myelomonocytic leukemia
Juvenile myelomonocytic leukemia (JMML) is an aggressive hematologic malignancy with myeloproliferative characteristics that affects young children and is associated with significant morbidity and mortality. Leukemia stem cells (LSCs) have been shown to drive relapse and progression in JMML and incl...
ORGANISM(S): Homo sapiens (Human) 
2025-02-03 | PXD052910 | Pride
Jmml Surfaceomics Car-t cell Immunotherapy 
TranscriptomicsExomes of human leukemic JMML (Juvenile MyeloMonocytic Leukemia) xenografts in NSG or NSG-S mice (samples enriched in hCD45)
The study includes 14 patients with confirmed JMML and known somatic mutations (from exome data of paired tumoral and germline DNA). Bone marrow or peripheral blood mononucleated cells were injected in immundeficient mice to recapitulate the leukemia. Whole exome sequencing was performed in xenograf...
ORGANISM(S): Mus musculus 
2018-03-15 | E-MTAB-6467 | biostudies-arrayexpress
TranscriptomicsGene exprssion profile classification predicts clinical outcome in juvenile myelomonocytic leukemia
Gene expression analysis identified a specific signature of differentially expressed genes discriminating good and poor responders in JMML patients. Gene expression signatures were analyzed on two EWOG patient cohorts of pediatric JMML patients. Keywords: Expression data Class comparison between AM...
ORGANISM(S): Homo sapiens 
2009-12-31 | E-GEOD-14858 | biostudies-arrayexpress
GenomicsInflammatory response in HSPC of PTPN11-mutated JMML
Inflammatory response in HSPC of PTPN11-mutated JMML
PRJNA759790 | ENA
ProteomicsProteomic analysis of an induced pluripotent stem cell model reveals strategies to treat Juvenile Myelomonocytic Leukaemia
Juvenile myelomonocytic leukemia (JMML) is an aggressive myeloproliferative neoplasm of early childhood with a poor survival rate thus there is a requirement for improved treatment strategies. Induced pluripotent stem cells offer the ability to model disease and develop new treatment strategies. JMM...
ORGANISM(S): Homo sapiens (Human) 
2019-10-30 | PXD014708 | Pride
Ptpn11 Jq1 Noonan syndrome Jmml Cbl0137 
UnknownJMML genomics and decisions.
Not available
S-EPMC6245977 | biostudies-literature
GenomicsRole of BTK and PI3K-P110d in JMML
Role of BTK and PI3K-P110d in JMML
PRJNA769612 | ENA
GenomicsTranscriptome analysis of JMML patients compare to healthy prenatal and postnatal samples.
Transcriptome analysis of JMML patients compare to healthy prenatal and postnatal samples.
PRJNA1112163 | ENA
GenomicsTranscriptome and methylation analysis of JMML patients compare to healthy prenatal and postnatal samples.
Transcriptome and methylation analysis of JMML patients compare to healthy prenatal and postnatal samples.
PRJNA817424 | ENA
TranscriptomicsInflammatory response in HSPC of PTPN11-mutated JMML
Activating mutations in PTPN11 gene are the most frequent in JMML patients. Here we explore the transcriptome of HSPC (hematopoietic stem and progenitor cells) sorted from sporadic JMML patients with PTPN11 mutation and from healthy age matched donnors. Bulk transcriptome of sorted HSPC reveals an i...
ORGANISM(S): Homo sapiens 
2021-09-06 | GSE183252 | GEO
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