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ProteomicsThermal proteome profiling of JQ1
Goal of this experiment was the identification of proteins affected in their thermal stability by JQ1.
ORGANISM(S): Homo sapiens (Human) 
2018-05-02 | PXD008638 | Pride
Jq1 Tpp 
ProteomicsMultiplexed proteome dynamics profiling of JQ1-PROTAC
Goal of this experiment was the differentiation of direct targets of induced degradation of the JQ1-PROTAC from downstream regulatory effects.
ORGANISM(S): Homo sapiens (Human) 
2018-05-02 | PXD008637 | Pride
Vhl Protac Mpdp Jq1 
TranscriptomicsBET Protein Inhibitor JQ1 Induces Cell Cycle Arrest in Mesenchymal Stem Cells
Efficacy and safety of anticancer drugs are traditionally studied using cancer cell lines and animal models. Recently, a potential anticancer agent, JQ1, an inhibitor of bromodomain and extra terminal (BET) protein, has been shown to promote apoptosis of cancerous cells by arresting them in G1 phase...
ORGANISM(S): Homo sapiens 
2016-02-12 | E-GEOD-70577 | biostudies-arrayexpress
Proteomics2 Dimensional Thermal proteome profiling of JQ1
Goal of this experiment was the identification of proteins affected dose dependently in their thermal stability by JQ1.
ORGANISM(S): Homo sapiens (Human) 
2018-05-02 | PXD008626 | Pride
2d-tpp Jq1 Tpp I-bet151 
TranscriptomicsKinetics after JQ1 treatment in liver cancer cell
Analysis of global gene expression after BRD4 inhibition by JQ1 in liver cancer cell lines SK-Hep1 Total RNA obtained from human liver cancer cell line SK-Hep1 cells after treatment of JQ1
ORGANISM(S): Homo sapiens 
2016-07-20 | E-GEOD-75908 | biostudies-arrayexpress
GenomicsBromodomain-Containing-Protein 4 (BRD4) Regulates RNA Polymerase II Serine 2 Phosphorylation in Human CD4+ T Cells
Transcriptional elongation by RNA polymerase II (Pol II) is regulated by positive transcription elongation factor b (P-TEFb) in association with Bromodomain-containing protein 4 (BRD4). We used genome-wide chromatin immunoprecipitation sequencing in primary human CD4+ T cells to reveal that BRD4 co-...
ORGANISM(S): Homo sapiens 
2012-11-14 | E-GEOD-33281 | biostudies-arrayexpress
TranscriptomicsDifferential gene expression in neuroblastoma cells after treatment with vehicle control, JQ1, panobinostat, or combination of JQ1 and panobinostat
The bromodomain inhibitor JQ1 and the histone deacetylase inhibitor panobinostat induce synergistic anticancer effects We analyzed whether JQ1 and panobinostat synergistically modulate gene expression Neuroblastoma SK-N-BE(2) cells were treated with vehicle control, 1 microM JQ1, 10 nM panobinostat,...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-68690 | biostudies-arrayexpress
TranscriptomicsGlobal mRNA expression profiling of murine primary PDAC cells following JQ1 or SAHA monotherapy as well as JQ1-SAHA combination therapy
Global mRNA expression profiles of murine primary PDAC cells following JQ1 or SAHA monotherapy as well as JQ1-SAHA combination therapy were collected using Affymetix mouse whole genome array (Mouse Genome 430A 2.0 Array) . Primary PDAC cells isolated from Ptf1aCre/+;Kras+/LSL-G12D;p53lox/lox (Kras;p...
ORGANISM(S): Mus musculus 
2015-09-20 | E-GEOD-64836 | biostudies-arrayexpress
TranscriptomicsJQ1 modulates inflammatory related-genes in human renal tubular epithelial cells
Selective bromodomains inhibitors block the interaction between diverse bromodomains and extraterminal domains (BET) proteins and acetylated proteins. These inhibitors have shown beneficial effects in cancers malignancies and experimental inflammation in mouse models, but data on renal diseases are ...
ORGANISM(S): Homo sapiens 
2016-07-01 | E-GEOD-71602 | biostudies-arrayexpress
TranscriptomicsDose response of the BET inhibitor JQ1 in Small-Cell Lung Cancer cell lines.
This is a Dose response experiment carried out using the BET inhibitor JQ1 in SCLC cell lines. Approximately 1x106 cells of cell lines, DMS-53, H69, H1694, H1048, H2227 were treated for 2 hours with a 12 point dose range of JQ1 (7500nM to 0.04nM). Lysates were collected at the end of the treatment ...
ORGANISM(S): Homo sapiens 
2015-05-31 | E-MTAB-3449 | biostudies-arrayexpress
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