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ProteomicsIdentification of proteins interacting with HA-FLAG-Eya1
To explore the spectrum of Eya1-interacting partner proteins, we thus generated a stable HEK293 cell line that constitutively express the 2HA–3FLAG-Eya1 (HF-Eya1) protein, purified HF-Eya1 from the cell extracts by a tandem affinity purification protocol to reduce background (first with anti-FLAG an...
ORGANISM(S): Homo sapiens (Human) 
2022-10-12 | PXD033955 | Pride
Eya1 Transcription coactivator Phosphatase 
UnknownBOR-syndrome-associated Eya1 mutations lead to enhanced proteasomal degradation of Eya1 protein.
Not available
S-EPMC3906160 | biostudies-literature
GenomicsChromatin remodelers interact with Eya1 and Six2 to control nephron progenitor cell self-renewal maintenance
Chromatin remodelers interact with Eya1 and Six2 to control nephron progenitor cell self-renewal maintenance
PRJNA767478 | ENA
UnknownThe PI3K/Akt signal hyperactivates Eya1 via the SUMOylation pathway.
Not available
S-EPMC4275428 | biostudies-literature
ProteomicsThe Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation: siEYA4 pY IP-MS
The Eyes Absent family of proteins (EYA1-4) are a biochemically unique group of tyrosine phosphatases known to be tumour promoting across a range of cancer types. To date, the molecular targets of EYA phosphatase activity remain largely uncharacterised. Here, we identify Polo-like kinase 1 (PLK1) as...
ORGANISM(S): Homo sapiens (Human) 
2024-02-26 | PXD036430 | Pride
Py ip Eya4 
ProteomicsThe Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation: PLK1 PRM
The aim of these experiments was to quantify PLK1 tyrosine phosphosites with respect to EYA4 and EYA1. PRM was performed on immunopurified PLK1. This was part of a larger project to characterize the effects of EYA4 mediated dephosphorylation on PLK1 functions.
ORGANISM(S): Homo sapiens (Human) 
2024-02-26 | PXD037064 | Pride
Plk1 prm 
GenomicsChromatin remodelers interact with Eya1 and Six2 to control nephron progenitor cell self-renewal maintenance
Eya1 interacts with Six1/2 to induce nephron fate and promote nephron progenitor self-renewal. Haploinsufficiency for these genes in humans causes kidney agenesis or hypoplasia. However, how the Eya1-centered network operates remains elusive. Here we identify Eya1's interacting factors via mass-spec...
ORGANISM(S): Mus musculus 
2021-10-01 | GSE185050 | GEO
UnknownEYA1 promotes cell migration and tumor metastasis in hepatocellular carcinoma.
Not available
S-EPMC6511787 | biostudies-literature
UnknownThe Eya1 phosphatase promotes Shh signaling during hindbrain development and oncogenesis.
Not available
S-EPMC4418443 | biostudies-literature
TranscriptomicsThe transcriptional coactivator Eya1 exerts transcriptional repressive activity by interacting with REST corepressors and DNA recognition sequences to maintain nephron progenitor identity [RNA-seq]
Eya1 is critical for specifying and maintaining nephron progenitor cells (NPCs). It belongs to a protein family known as phosphatase-transcriptional activator but without intrinsic DNA-binding activity. However, the Eya1-centered network and the spectrum of its interaction partners are underexplored...
ORGANISM(S): Mus musculus 
2022-10-19 | GSE202956 | GEO
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