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MetabolomicsMetabolic alterations caused by the mutation and overexpression of the Tmem135 gene
Mitochondria are highly dynamic organelles undergoing fusion, fission and degradation. Although mitochondria are known to be essential for cellular metabolism, it is not fully understood how mitochondrial dynamics affect cellular metabolism. We previously identified a mouse gene, transmembrane prote...
2021-02-12 | MTBLS1410 | MetaboLights
TranscriptomicsTranscription profiling of rat eye eQTL experiment
We used expression quantitative trait locus mapping in the laboratory rat (Rattus norvegicus) to gain a broad perspective of gene regulation in the mammalian eye and to identify genetic variation relevant to human eye disease. Of >31,000 gene probes represented on an Affymetrix expression microarray...
ORGANISM(S): Rattus norvegicus 
2008-06-14 | E-GEOD-5680 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of eye tissues from C57BL/6J background mice at 1.5 h and 9.0 h after light onset
We report RNA-Seq experiments of whole eye tissues from C57BL/6J background mice at 1.5 h and 9.0 h after light onset to better understand photoreceptor phagocytosis Examine ocular tissue from mice at different time points
ORGANISM(S): Mus musculus 
2013-08-07 | E-GEOD-48974 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of eye tissues from A/J, BALB/c, and C57BL/6 background mice
We report RNA-Seq experiments of whole eye tissues from A/J, BALB/c, and C57BL/6 background mice. Examine ocular tissue from 3 different background mice that display varying rates of retinal degeneration.
ORGANISM(S): Mus musculus 
2012-06-07 | E-GEOD-38359 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of wild type fly heads (CantonS) and eye-less fly heads (sine occulis)
To identify the eye-enriched genes by comparing the mRNA expression profiles from wild type fly heads (CantonS) and eye-less fly heads (sine occulis).
ORGANISM(S): Drosophila melanogaster 
2012-05-17 | E-MEXP-49 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of stalk-eyed fly lines selected for divergent eyespan
Eye-stalks of some flies exhibit extreme sexual dimorphism, but little is known about the genetic mechanisms producing variation in these ornamental traits. Therefore, we constructed an EST database of genes expressed in the developing eye-antennal imaginal disc of the highly dimorphic species, Tele...
ORGANISM(S): Teleopsis dalmanni 
2010-06-24 | E-GEOD-15444 | biostudies-arrayexpress
TranscriptomicsForm deprivation modulates retinal neurogenesis in primate experimental myopia
Juvenile primates develop myopia when their visual experience is degraded by lid fusion. In response to the abnormal visual input, retinal neural networks cause an excessive growth of the postequatorial segment of the eye, but the mechanism underlying this axial elongation is unknown. By combining a...
ORGANISM(S): Macaca mulatta 
2010-07-01 | E-GEOD-3300 | biostudies-arrayexpress
ProteomicsThe life history of recessive deleterious alleles as seen through the eyes of a honey bee (Apis mellifera)
Deleterious mutations arise continually in natural populations, yet their full life histories—from origin to elimination—are rarely observed directly. Most understanding of mutational fate in the wild comes from indirect inference rather than from tracking a single mutation across generations. Haplo...
ORGANISM(S): Apis mellifera (Honeybee) 
2026-09-07 | PXD075256 | Pride
Eye mutation Ivory mutation Cinnabar Hymenoptera Genome-wide association study Recurrent mutation 
TranscriptomicsWnt ligands from the embryonic surface ectoderm regulate bimetallic strip optic cup morphogenesis in the mouse
Wnt signaling in early eye development, specifically the lens placode shows expression of 12 out of 19 Wnt ligands. We these Wnt activities were suppressed using conditional deletion of Wntless, dramatic phenotypic changes in morphogensis occurred. Microarray analysis of the genes that were changed...
ORGANISM(S): Mus musculus 
2015-01-22 | E-GEOD-65154 | biostudies-arrayexpress
TranscriptomicsExpression data of wild type, dDP mutant, and de2f1, deleted in the posterior, Drosophila 3rd instar larval eye imaginal discs
Apoptosis is an important process to eliminate cells from tissue which have incurred irreparable DNA damage. While dE2F1/dDP complexes respond to such damage by transcriptionally activating apoptotic genes, previous data suggests that activation of the previously characterized apoptotic target genes...
ORGANISM(S): Drosophila melanogaster 
2013-11-25 | E-GEOD-39389 | biostudies-arrayexpress
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