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ProteomicsAltered turnover of the CNS myelin protein Opalin in a mouse model of hereditary spastic paraplegia 35
Fatty acid 2-hydroxylase (FA2H) is responsible for the synthesis of 2-hydroxylated fatty acids, which are a building block of sphingolipids. This 2-hydroxylated sphingolipids can be found in various tissues such as brain, spinal cord, skin, testis, ovary, kidney, stomach, or intestine with a notably...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-04 | PXD021021 | Pride
Cns Mice Hereditary spastic paraplegia 35 Sphingolipids Neurodegeneration Disease model Fa2h Tmt Time course Myelin Fatty acid hydroxylation Isobaric labeling Fatty acid 2-hydroxylase Opalin 
UnknownHeterozygous FA2H mutations in autism spectrum disorders.
Not available
S-EPMC4219428 | biostudies-literature
UnknownCentral nervous system dysfunction in a mouse model of FA2H deficiency.
Not available
S-EPMC3094470 | biostudies-literature
UnknownFA2H is responsible for the formation of 2-hydroxy galactolipids in peripheral nervous system myelin.
Not available
S-EPMC2662131 | biostudies-literature
UnknownFA2H Exhibits Tumor Suppressive Roles on Breast Cancers via Cancer Stemness Control.
Not available
S-EPMC6821679 | biostudies-literature
UnknownUniparental disomy of chromosome 16 unmasks recessive mutations of FA2H/SPG35 in 4 families.
Not available
S-EPMC4940069 | biostudies-literature
UnknownNovel Homozygous FA2H Variant Causing the Full Spectrum of Fatty Acid Hydroxylase-Associated Neurodegeneration (SPG35).
Not available
S-EPMC10815826 | biostudies-literature
ProteomicsAge-dependent increase in Schmidt-Lanterman incisures and a Cadm4 associated membrane skeletal complex in fatty acid 2-hydroxylase deficient mice, a mouse model of spastic paraplegia SPG35
Fatty acid 2-hydroxylase (FA2H) is responsible for the synthesis of 2-hydroxylated fatty acids, which are a building block of sphingolipids. This 2-hydroxylated sphingolipids can be found in various tissues such as brain, spinal cord, skin, testis, ovary, kidney, stomach, or intestine with a notably...
ORGANISM(S): Mus musculus (Mouse) 
2022-04-22 | PXD030244 | Pride
Isobaric labelling Schmidt-lanterman incisures Mice Hereditary spastic paraplegia type 35 Sphingolipids Neurodegeneration Sciatic nerves Disease model Fa2h Tmt Time course Myelin Fatty acid hydroxylation Pns Fatty acid 2-hydroxylase 
UnknownThe role of the LncRNA-FA2H-2-MLKL pathway in atherosclerosis by regulation of autophagy flux and inflammation through mTOR-dependent signaling.
Not available
S-EPMC6748100 | biostudies-literature
UnknownCerebral Iron Accumulation Is Not a Major Feature of FA2H/SPG35.
Not available
S-EPMC6353525 | biostudies-literature
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