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TranscriptomicsSingle-cell 5' Gene Expression and V(D)J Amplification (10X Genomics) of splenic CD4+ T cells from Plasmodium chabaudi infected mice
To associate gene expression profiles with specific features of the splenic CD4+ T-cell repertoire generated during a blood stage P. chabaudi infection, we obtained both transcriptomic and T-cell receptor data from 2 infected mice at 7 days following infection.
ORGANISM(S): Mus musculus 
2020-11-13 | E-MTAB-9691 | biostudies-arrayexpress
TranscriptomicsAfter demyelination in the adult CNS, oligodendrocyte precursor cells revert to an immature mRNA profile and express immune cues favoring their migration
In multiple sclerosis (MS) and experimental models of demyelination, myelin repair is mostly achieved by oligodendrocyte precursor cells (OPCs). To gain insight into the biological specificity of these adult precursors, in the perspective to better understand why remyelination often fails in MS, we ...
ORGANISM(S): Mus musculus 
2014-11-06 | E-GEOD-48872 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of thymocyte differentiation in knockout mouse models
Microarray experiment with whole thymi from genetically enginereed mice, with purified thymocyte samples and with cell lines.
ORGANISM(S): Mus musculus 
2004-06-30 | E-MEXP-96 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of normal human tonsillar cell subpopulations FACS sorted based on expression of cell surface markers
To characterize the progenitor-enriched CD44+NGFR+ cells present in the crypt and surface regions of the tonsil, we used an Illumina array system to analyze the transcriptome of these cells isolated from the tonsillar crypt and surface regions of three different individuals as well as the total epit...
ORGANISM(S): Homo sapiens 
2015-10-29 | E-GEOD-69767 | biostudies-arrayexpress
Transcriptomics454 Life Sciences/Roche and Illumina sequencing of small RNAs from planarian samples
Freshwater planarian flatworms possess uncanny regenerative capacities mediated by abundant and collectively totipotent adult stem cells. Key functions of these cells during regeneration and tissue homeostasis have been shown to depend on PIWI, a molecule required for piRNA expression in planarians....
ORGANISM(S): Schmidtea mediterranea 
2009-06-30 | E-GEOD-16159 | biostudies-arrayexpress
TranscriptomicsGene expression in lung cells expressing MycER/KrasG12D from a transgenic mouse model of non-small cell lung cancer
A transgenic mouse model of Kras-driven lung adenocarcinoma, with reversible activation of Myc, was used to explore the effect of Myc activity on lipid metabolism in lung tumours. Gene expression analysis links lipid metabolism, transport and storage to Myc activity. Lung cells from adeno-cre infec...
ORGANISM(S): Mus musculus 
2020-08-10 | E-MTAB-9131 | biostudies-arrayexpress
TranscriptomicsExpression analysis from Runx2-deficient pDCs from mouse
Plasmacytoid dendritic cells (pDCs) rapidly produce type I interferon (IFN-I) in response to viruses and are essential for antiviral immune responses. Although related to classical dendritic cells (cDCs) in their development and expression profile, pDCs possess many distinct features. Unlike cDCs, p...
ORGANISM(S): Mus musculus 
2013-09-30 | E-GEOD-49859 | biostudies-arrayexpress
TranscriptomicsscRNA-seq analysis of lung neutrophils from mice, 24 hours after intranasal exposure to vehicle, 100 ng LPS and 10 µg LPS
Mice intranasally exposed to a low dose of LPS (i.e., 100 ng) are prone to develop features of allergic asthma upon subsequent exposure to house dust mites (HDM) allergens, while mice exposed to vehicle or 100 µg LPS do not develop such features. In order to understand the mechanisms that promote al...
ORGANISM(S): Mus musculus 
2019-07-25 | E-MTAB-6902 | biostudies-arrayexpress
TranscriptomicsIdentification of stem cell populations in sweat glands and ducts: roles in homeostasis and wound repair
Sweat glands are abundant glands of our body and essential for thermoregulation. Like mammary glands, they originate from epidermal progenitors. However, they display few signs of cellular turnover, and whether they have stem cells and tissue regenerative capacity remain largely unexplored. Here we ...
ORGANISM(S): Mus musculus 
2013-01-02 | E-GEOD-37274 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of myeloid cells (neutrophils, macrophages and dendritic cells) isolated from the spinal cord of mice with experimental autoimmune encephalomyelitis (EAE)
We have discovered that neutrophils that infiltrate the spinal cord of mice with EAE, a model of multiple sclerosis, but not intravascular neutrophils that crawl on the luminal endothelial surface, bear on their surface the adhesion molecule Icam1. The goal of this experiment was to use Icam1 to iso...
ORGANISM(S): Mus musculus 
2017-11-10 | E-MTAB-6160 | biostudies-arrayexpress
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