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TranscriptomicsRecombinant and plasma-derived Factor VIII products induce distinct splenic cytokine microenvironments in hemophilia A
To investigate the gene expression in dendritic cells after treating hemiphilic mice with HBSS, plasma derived or recombinant factor VIII Gene expression in dendritic cells were measured 24 hours post treatment Hemophilic mice with treated with either (HBSS, rFVIII or pdFVIII) 24 hours post treatmen...
ORGANISM(S): Mus musculus 
2010-05-19 | E-GEOD-15809 | biostudies-arrayexpress
GenomicsCorrection of a Factor VIII genomic inversion with designer recombinases
Despite advances in nuclease-based genome editing technologies, correcting human disease-causing genomic inversions remains a challenge. Here, we describe the potential use of a recombinase-based system to correct the 140 kb inversion of the F8 gene frequently found in patients diagnosed with severe...
EGAS00001005496 | EGA
ProteomicsMechano‐covalent protection 1 of procoagulant factor VIII by von Willebrand factor
von Willebrand factor (VWF) is the protective carrier of procoagulant factor VIII (FVIII) in the shear forces of the circulation, prolonging its half‐life and delivering it to the developing thrombus. VWF∙FVIII complex formation is characterized by catch‐bond behavior in which force first decelerat...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD034866 | Pride
Cysteines Factor fviii Von willebrand factor Disulphide bonds 
GenomicsCorrection of a Factor VIII genomic inversion with designer recombinases
Correction of a Factor VIII genomic inversion with designer recombinases
PRJNA669049 | ENA
Genomics
Factor VIII Exon16 SHAPE MaP-seq
PRJNA953445 | ENA
UnknownFactor VIII/V C-domain swaps reveal discrete C-domain roles in factor VIII function and intracellular trafficking.
Not available
S-EPMC5395109 | biostudies-literature
GenomicsB-Domain deleted Factor VIII exhibits notable differences in intracellular processing and cellular responses when compared to full length Factor VIII
B-Domain deleted Factor VIII exhibits notable differences in intracellular processing and cellular responses when compared to full length Factor VIII
PRJNA1120570 | ENA
TranscriptomicsRecombinant and plasma-derived Factor VIII products induce distinct splenic cytokine microenvironments in hemophilia A
To investigate the gene expression in dendritic cells after treating hemiphilic mice with HBSS, plasma derived or recombinant factor VIII Gene expression in dendritic cells were measured 24 hours post treatment
ORGANISM(S): Mus musculus 
2009-04-30 | GSE15809 | GEO
UnknownMembrane-binding properties of the Factor VIII C2 domain.
Not available
S-EPMC3670696 | biostudies-literature
UnknownInhibitors of factor VIII in black patients with hemophilia.
Not available
S-EPMC2761028 | biostudies-literature
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