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GenomicsMeta-analysis of Genome-Wide-Association Sudies for plasma Factor XI
Coagulation factor XI (FXI) has become increasingly interesting for its role in pathogenesis of thrombosis. We performed a genome-wide association study (GWAS) for plasma FXI levels, using novel data imputed to the 1000 Genomes reference panel. Individual GWAS analyses, including a total of 16,169 E...
EGAS00001002123 | EGA
TranscriptomicsA comprehensive Xist interactome reveals cohesin repulsion and an RNA-directed chromosome conformation
The inactive X chromosome (Xi) serves as a model to understand gene silencing on a global scale. Here, we perform identification of direct RNA interacting proteins? (iDRiP) to isolate a comprehensive protein interactome for Xist, an RNA required for Xi silencing. We discover multiple classes of inte...
ORGANISM(S): Mus musculus 
2015-06-19 | E-GEOD-67516 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis with post-transcriptionally silenced Myosin XI-K
This study was aimed to determine roles of individual myosins in organelle trafficking in plant cell. Expression of Myosin XI-K was suppressed in transgenic A.thaliana by using RNAi approach. To ensure that the RNAi-induced gene silencing was specific and did not affect expression of other myosins,...
ORGANISM(S): Arabidopsis thaliana 
2008-06-13 | E-GEOD-5431 | biostudies-arrayexpress
UnknownFactor XI Inhibitors: A New Horizon in Anticoagulation Therapy.
Not available
S-EPMC10899133 | biostudies-literature
UnknownFactor XI antisense oligonucleotide for prevention of venous thrombosis.
Not available
S-EPMC4367537 | biostudies-literature
UnknownFactor XI(a) inhibitors for thrombosis: an updated patent review (2016-present).
Not available
S-EPMC7515655 | biostudies-literature
UnknownAn update on factor XI structure and function.
Not available
S-EPMC5776729 | biostudies-literature
UnknownProspective study of circulating factor XI and incident venous thromboembolism: The Longitudinal Investigation of Thromboembolism Etiology (LITE).
Not available
S-EPMC4618026 | biostudies-literature
TranscriptomicsXi-reactivation in female human induced pluripotent stem cells (hiPSCs)
Female human induced pluripotent stem cell (hiPSC) lines exhibit considerable variability in X-inactivation status. Some lines maintain one transcriptionally active X chromosome (Xa) and one inactive X (Xi) from donor cells. However, hiPSC lines that have two Xas are infrequently produced. We sho...
ORGANISM(S): Homo sapiens 
2013-02-06 | E-GEOD-44044 | biostudies-arrayexpress
UnknownFactor XI Deficiency Alters the Cytokine Response and Activation of Contact Proteases during Polymicrobial Sepsis in Mice.
Not available
S-EPMC4821616 | biostudies-literature
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