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TranscriptomicsCharacterization of active piRNAs and piRNA machinery in WRR-1 cells deficient for the Hippo pathway (deficient for the warts tumor suppressor) and expressing activated RasV12
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Drosophila melanogaster 
2016-08-01 | E-GEOD-83877 | biostudies-arrayexpress
TranscriptomicsCharacterization of active piRNAs and piRNA machinery in WRR-1 cells deficient for the Hippo pathway (deficient for the warts tumor suppressor) and expressing activated RasV12 (RNA-seq)
We have found that oncogenic Ras combined with loss of the Hippo tumour-suppressor pathway reactivates a primary piRNA pathway in Drosophila somatic cells, coincident with oncogenic transformation. In these cells, Piwi becomes loaded with piRNAs derived from generative loci, which are normally restr...
ORGANISM(S): Drosophila melanogaster 
2016-08-01 | E-GEOD-83843 | biostudies-arrayexpress
TranscriptomicsCharacterization of active piRNAs and an piRNA machinery in WRR-1 cells deficient for the Hippo pathway (deficient for the warts tumor suppressor) and expressing activated RasV12 (small RNA)
We have found that oncogenic Ras combined with loss of the Hippo tumour-suppressor pathway reactivates a primary piRNA pathway in Drosophila somatic cells, coincident with oncogenic transformation. In these cells, Piwi becomes loaded with piRNAs derived from generative loci, which are normally restr...
ORGANISM(S): Drosophila melanogaster 
2016-08-01 | E-GEOD-83871 | biostudies-arrayexpress
TranscriptomicsProfiling and comparison of miRNA populations in male and female tissues from Drosophila melanogaster at various stages
By surveying miRNA populations in each sex, we identified sets of miRNAs differentially expressed in male and female tissues across various stages of development. Small RNAs cloning of dissected male and female tissues from Drosophila melanogaster at various stages
ORGANISM(S): Drosophila melanogaster 
2014-08-01 | E-GEOD-57029 | biostudies-arrayexpress
TranscriptomicsDiscovery of progenitor signatures by time series synexpression analysis during Drosophila cell immortalization [Microarray Expression]
To characterize the sequence of events associated with RasV12 immortalization of Drosophila embryonic cells, we generated transcriptional time series during cell line establishment, from primary cultures until passage (P) 19. We generated two transcriptional time series from two cell lines (R3 and R...
ORGANISM(S): Drosophila melanogaster 
2015-09-23 | E-GEOD-73335 | biostudies-arrayexpress
TranscriptomicsDiscovery of progenitor signatures by time series synexpression analysis during Drosophila cell immortalization [RNA-Seq]
To characterize the sequence of events associated with RasV12 immortalization of Drosophila embryonic cells, we generated transcriptional time series during cell line establishment, from primary cultures until passage (P) 19. We generated three transcriptional time series from three cell lines (R1, ...
ORGANISM(S): Drosophila melanogaster 
2015-09-24 | E-GEOD-73353 | biostudies-arrayexpress
TranscriptomicsMinotaur is critical for primary piRNA biogenesis [RNA-Seq]
Piwi proteins and their associated small RNAs are essential for fertility in animals. This is due, in part, to their roles in guarding germ cell genomes against the activity of mobile genetic elements. piRNA populations direct Piwi proteins to silence transposon targets and as such form a molecula...
ORGANISM(S): Drosophila melanogaster 
2013-04-27 | E-GEOD-46423 | biostudies-arrayexpress
TranscriptomicsMinotaur is critical for primary piRNA biogenesis [smallRNA-Seq]
Piwi proteins and their associated small RNAs are essential for fertility in animals. This is due, in part, to their roles in guarding germ cell genomes against the activity of mobile genetic elements. piRNA populations direct Piwi proteins to silence transposon targets and as such form a molecula...
ORGANISM(S): Drosophila melanogaster 
2013-04-27 | E-GEOD-46422 | biostudies-arrayexpress
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