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UnknownSuper-resolution microscopy reveals that mammalian mitochondrial nucleoids have a uniform size and frequently contain a single copy of mtDNA.
Not available
S-EPMC3158146 | biostudies-literature
ProteomicsMice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria
Replication of mammalian mitochondrial DNA (mtDNA) is an essential process that requires high fidelity and control at multiple levels to ensure proper mitochondrial function. Mutations in the mitochondrial genome maintenance exonuclease 1 (MGME1) gene were recently reported in mitochondrial disease ...
ORGANISM(S): Homo sapiens (Human) 
2018-07-11 | PXD009138 | Pride
Mtdna deletions Mgme1 knock out Progeria 
ProteomicsThe mitochondrial single-stranded DNA binding protein directs RNA primer formation for mtDNA replication
Single-stranded DNA (ssDNA) binding proteins protect regions of ssDNA formed during processes such as DNA replication and repair. We here devise a genetic screen and identify the mitochondrial ssDNA-binding protein (mtSSB) as a key regulator of mtDNA levels. In mitochondria, RNA synthesis from the l...
ORGANISM(S): Mus musculus (Mouse) 
2021-05-19 | PXD021799 | Pride
Mtdna Tmt Replication Mtssb 
ProteomicsProteolytic processing promotes the decatenation activity of human mitochondrial TOP3A; BioID
The TOP3A gene encodes protein products that are targeted to both the nucleus and to mitochondria. The nuclear isoform of TOP3A is required for the resolution of double Holliday junctions during homologous recombination, while the mitochondrial isoform of TOP3A separates hemicatenated daughter mitoc...
ORGANISM(S): Homo sapiens (Human) 
2025-09-30 | PXD063285 | Pride
Top3a Label-free Bioid 
UnknownMGME1 processes flaps into ligatable nicks in concert with DNA polymerase γ during mtDNA replication.
Not available
S-EPMC4937333 | biostudies-literature
UnknownThe exonuclease activity of DNA polymerase γ is required for ligation during mitochondrial DNA replication.
Not available
S-EPMC4557304 | biostudies-literature
UnknownCross-strand binding of TFAM to a single mtDNA molecule forms the mitochondrial nucleoid.
Not available
S-EPMC4568684 | biostudies-literature
UnknownStress promotes Arabidopsis - Piriformospora indica interaction.
Not available
S-EPMC4973781 | biostudies-literature
ProteomicsSubcellular fraction kidney proteomics in MGME1 knockout mice
Metabolic dysregulation can lead to inflammatory responses. Imbalanced nucleotide synthesis triggers the release of mitochondrial DNA (mtDNA) to the cytosol and an innate immune response by cGAS-STING signaling. However, how nucleotide deficiency drives mtDNA dependent inflammation has not been eluc...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-25 | PXD053639 | Pride
Mgme1 Mitochondria Kidney 
UnknownComplementation between polymerase- and exonuclease-deficient mitochondrial DNA polymerase mutants in genomically engineered flies.
Not available
S-EPMC4773887 | biostudies-literature
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