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TranscriptomicsIdentification of miRNA targets in breast cancer cells
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ORGANISM(S): Homo sapiens 
2013-10-21 | E-GEOD-48162 | biostudies-arrayexpress
TranscriptomicsExpression data of breast tumors in MMTV-PyMT+ female mice treated with DPM or vehicle
Dipyridamole (DPM) is widely used to prevent strokes and vascular thrombosis. Combination therapy of DPM and antimetabolites has shown synergistic anticancer activity. This study investigated the chemopreventive effects of DPM in the mouse mammary tumor virus promoter driven polyoma middle T oncopro...
ORGANISM(S): Mus musculus 
2013-06-06 | E-GEOD-43833 | biostudies-arrayexpress
TranscriptomicsIdentification of miRNA targets in breast cancer cells (Ago2-IP)
miRNAs regulate mRNA stability and translation through the action of the RNAi-induced silencing complex. In this study, we systematically identified endogenous miRNA target genes by using AGO2 immunoprecipitation (AGO2-IP) and microarray analyses in two breast cancer cell lines, MCF7 and MDA-MB-231,...
ORGANISM(S): Homo sapiens 
2013-10-21 | E-GEOD-48158 | biostudies-arrayexpress
TranscriptomicsIdentification of miRNA targets in breast cancer cells (DICER1 and DROSHA knockdown)
miRNAs regulate mRNA stability and translation through the action of the RNAi-induced silencing complex. In this study, we systematically identified endogenous miRNA target genes by using AGO2 immunoprecipitation (AGO2-IP) and microarray analyses in two breast cancer cell lines, MCF7 and MDA-MB-231,...
ORGANISM(S): Homo sapiens 
2013-10-21 | E-GEOD-48160 | biostudies-arrayexpress
TranscriptomicsCrosstalk between the STAT3, NF-kB and Notch signaling pathways in glioblastoma stem cells
In this study, we describe a novel relationship between glioblastoma CSCs and the Notch pathway, which involves the constitutive activation of STAT3 and NF-κB signaling. We demonstrate that adherent glioma CSCs exhibit characteristics previously described for CSCs grown in suspension culture. The ex...
ORGANISM(S): Homo sapiens 
2013-06-19 | E-GEOD-48079 | biostudies-arrayexpress
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