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GenomicsGenome-wide maps of the total and lysine methylated enriched pools of peroxisome proliferating activated receptor gamma (pparg) co-activator 1 alpha (ppargc1a) in Hepa 1-6 cells
We report the application of single nucleotide sequencing technology for high-throughput profiling of ppargc1a in mouse hepatome cells (Hepa1-6). By obtaining 1.2 billion bases of sequence from chromatin immunoprecipitated DNA, we generated genome-wide maps of ppargc1a sin mouse hepatoma cells. We ...
ORGANISM(S): Mus musculus 
2017-05-01 | E-GEOD-57852 | biostudies-arrayexpress
UnknownAge-related compositional changes and correlations of gut microbiome, serum metabolome, and immune factor in rats.
Not available
S-EPMC8110635 | biostudies-literature
TranscriptomicsComprehensive role of Zfp217 in m6A methylation [RIP-seq]
Many transcriptional and epigenetic networks must be integrated to maintain self-renewal and pluripotency in embryonic stem cells (ESCs) and to enable induced pluripotent stem cell (iPSC) reprogramming. Here, we explore the role of Zfp217and Mettl3 as RNA-binding proteins. Identification and charac...
ORGANISM(S): Mus musculus 
2015-10-30 | E-GEOD-65733 | biostudies-arrayexpress
TranscriptomicsComprehensive role of Zfp217 in m6A methylation [RNA-seq]
Comprehensive RNA-seq experiments in control and zfp217 shRNA infected cells delineate a Zfp217-driven network required for ES cell self-renewal. RNA-seq was used to measure gene expression levels in luciferase control and Zfp217 short hairpin RNA (shRNA) infected mouse stem cells
ORGANISM(S): Mus musculus 
2015-10-30 | E-GEOD-65731 | biostudies-arrayexpress
TranscriptomicsComprehensive role of Zfp217 in m6A methylation [MeRIP-seq]
Many transcriptional and epigenetic networks must be integrated to maintain self-renewal and pluripotency in embryonic stem cells (ESCs) and to enable induced pluripotent stem cell (iPSC) reprogramming. Here, we explore the role of Zfp217 as a key transcriptional factor in maintaining ES cell self-...
ORGANISM(S): Mus musculus 
2015-10-30 | E-GEOD-65734 | biostudies-arrayexpress
TranscriptomicsComprehensive role of Zfp217 in m6A methylation [RNA-seq RA]
Mouse stem cells were differenciated with retinoic acid and cells were harvested at the indicated time points. RNA-seq was used to measure gene expression levels in retinoic acid-differentiated mouse stem cells
ORGANISM(S): Mus musculus 
2015-10-30 | E-GEOD-65732 | biostudies-arrayexpress
TranscriptomicsExpression data from OVCAR-3 cells overexpressing histone H1.3
Ovarian cancer is a deadly gynecological malignancy for which novel biomarkers and therapeutic targets are imperative for improving survival. To investigate the role of histone H1 in ovarian cancer cells, we overexpress a histone H1 variant, H1.3, in the OVCAR-3 epithelial ovarian cancer cell line. ...
ORGANISM(S): Homo sapiens 
2014-10-31 | E-GEOD-61692 | biostudies-arrayexpress
TranscriptomicsRTN1 IS A NOVEL MEDIATOR FOR PROGRESSION OF KIDNEY DISEASE
Gene expression profiling of kidneys from the murine model of HIV-associated nephropathy (HIVAN) identified an association between the expression of an endoplasmic reticulum (ER)-associated protein reticulon-1, RTN1, and the severity of kidney disease. Of the three known RTN1 isoforms, only RTN1A pr...
ORGANISM(S): Mus musculus 
2015-05-20 | E-GEOD-69074 | biostudies-arrayexpress
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