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ProteomicsHuman urinary protein and glycopeotein LC-MSMS
N-glycosylation is one of the most common and important post-translational modifications, and plays a vital role in the control of many biological processes. The increasing discovery of abnormal alterations of N-linked glycans associated with many diseases leads to greater demands for rapid and effi...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD024639 | Pride
Lc-msms Urinary proteins 
ProteomicsOGA-mediated protein glycosylation regulates pluripotency states in human embryonic stem cells
In our previous study, we uncovered that OGA significantly elevated in naïve hESC. Therefore, we sought to investigate the effects of O-GlcNAc on hESC and the interconvert of both pluripotent states. Depletion of OGA, which results in global O-GlcNAcylation increased, would impair naïve hESC pluripo...
ORGANISM(S): Homo sapiens (Human) 
2024-08-10 | PXD041605 | Pride
Human embryonic stem cells，oga，o-glcnac 
ProteomicsO-GlcNAcylation regulates epidermal growth factor receptor intracellular trafficking and signaling
Ligand-stimulated epidermal growth factor receptor (EGFR) signaling plays fundamental roles in normal cell physiology, such as cell growth, cell proliferation, and cell survival. Deregulation of EGFR signaling contributes to the development and progression of diseases including cancer. Despite its e...
ORGANISM(S): Homo sapiens (Human) 
2022-04-04 | PXD031700 | Pride
Endosomal sorting Membrane receptors O-glcnacylation Egfr 
ProteomicsNovel molecular glue degraders against broad range of myeloma and lymphoma cancer cell lines
Targeted protein degradation of neosubstrates plays a crucial role in treating hematological cancers with IMiDs therapy. However, the inevitable drug resistance and hematological toxicities remain persistent challenges, limiting their clinical efficacy. Herein, we present the discovery of a lead deg...
ORGANISM(S): Homo Sapiens 
2024-06-22 | PXD053334 |
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