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ProteomicsCrosslinking/mass spectrometry analysis of Fanconi anemia (FA) pathway FANCD2-FANCI complexes
DNA interstrand crosslinks (ICLs) are repaired by the Fanconi anemia (FA) pathway. The FA pathway is activated by phosphorylation of FANCI in FANCD2-FANCI complex. To investigate how phosphorylation regulates FA pathway activation and function, recombinant FANCD2-FANCI complexes prepared using eithe...
ORGANISM(S): Cellular Organisms 
2022-11-18 | PXD031632 | JPOST Repository
ProteomicsCrosslinking mass spectrometry (CLMS) analysis of monoubiquitinated FANCD2-FANCI complex
Vertebrate DNA crosslink repair excises toxic replication-blocking DNA crosslinks. Numerous factors involved in crosslink repair have been identified, and mutations in their corresponding genes cause Fanconi anemia (FA). A key step in crosslink repair is monoubiquitination of the FANCD2-FANCI hetero...
ORGANISM(S): Gallus gallus (Chicken) 
2020-03-09 | PXD017020 | Pride
Crosslinking mass spectrometry Fancd2-fanci comple Monoubiquitination Fanconi anemia pathway 
GenomicsFanconi Anemia pathway regulation by FANCI in prostate cancer
Fanconi Anemia pathway regulation by FANCI in prostate cancer
PRJNA870033 | ENA
GenomicsEffect of a long non-coding RNA, lnc-FANCI-2 on host transcriptome.
Effect of a long non-coding RNA, lnc-FANCI-2 on host transcriptome.
PRJNA788906 | ENA
TranscriptomicsFanconi Anemia pathway regulation by FANCI in prostate cancer
Prostate cancer is one of the leading causes of death among men worldwide and thus research on the genetic factors enabling the formation of treatment resistant cancer cells is crucial for improving patient outcomes.Here, we report a cell-line specific dependence on FANCI and related signalling path...
ORGANISM(S): Homo sapiens 
2023-09-29 | GSE211363 | GEO
TranscriptomicsEffect of a long non-coding RNA, lnc-FANCI-2 on host transcriptome.
To seek the function of lnc-FANCI-2 in high-risk HPV infected cancer cells, we knocked out lnc-FANCI-2 in CaSki cells (HPV16 positive) using CRISPR/Cas9 system.
ORGANISM(S): Homo sapiens 
2022-06-01 | GSE190904 | GEO
UnknownA Fanci knockout mouse model reveals common and distinct functions for FANCI and FANCD2.
Not available
S-EPMC6698648 | biostudies-literature
GenomicsOncogenic HPV E7 promotes the expression of a long noncoding RNA lnc-FANCI-2 via YY1 and miR-29a
Long noncoding RNAs (lncRNA) play diverse roles in biological processes, but their expression profiles and functions in cervical carcinogenesis remains unknown. By RNA-seq analyses of 18 clinical samples and validated by RT-qPCR analyses of 72 clinical samples, we provide the first evidence in this ...
ORGANISM(S): Homo sapiens 
2021-12-31 | GSE150227 | GEO
GenomicsOncogenic HPV E7 promotes the expression of a long noncoding RNA lnc-FANCI-2 via YY1 and miR-29a
Oncogenic HPV E7 promotes the expression of a long noncoding RNA lnc-FANCI-2 via YY1 and miR-29a
PRJNA631542 | ENA
UnknownFANCI is a negative regulator of Akt activation.
Not available
S-EPMC4889286 | biostudies-literature
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