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ProteomicsCrosslinking/mass spectrometry analysis of Fanconi anemia (FA) pathway FANCD2-FANCI complexes
DNA interstrand crosslinks (ICLs) are repaired by the Fanconi anemia (FA) pathway. The FA pathway is activated by phosphorylation of FANCI in FANCD2-FANCI complex. To investigate how phosphorylation regulates FA pathway activation and function, recombinant FANCD2-FANCI complexes prepared using eithe...
ORGANISM(S): Cellular Organisms 
2022-11-18 | PXD031632 | JPOST Repository
TranscriptomicsFanconi anemia proteins interact with CtBP1 and modulate the expression of the Wnt antagonist Dickkopf-1
Fanconi anemia (FA) is a genetic disorder characterized by congenital abnormalities, bone marrow failure and increased susceptibility to cancer. Of the fifteen FA proteins, Fanconi anemia group C (FANCC) is one of eight FA core complex components of the FA pathway. Unlike other FA core complex prote...
ORGANISM(S): Homo sapiens 
2013-04-05 | E-GEOD-43330 | biostudies-arrayexpress
TranscriptomicsBone marrow transcriptomal differences between wild type, Fancc-deficient, Fancg-deficient, and doubly deficient (Fancc/Fancg) mice.
Seeking to challenge the current dogma that the nuclear core-complex proteins function in an entirely epistatic manner, Dr. Clapp's group developed a new double-knockout mouse nullizygous for Fancc and Fancg. Because the hematopoietic phenotype was more severe than single knockout mice, we reasone...
ORGANISM(S): Mus musculus 
2010-07-30 | E-GEOD-22094 | biostudies-arrayexpress
GenomicsWhole-exome sequencing of Fanconi anemia
We performed whole-exome sequencing of two Fanconi anemia patients without mutation of known FA genes, and identified a novel FA gene FANCT.
EGAS00001001103 | EGA
GenomicsFANCD2 Activates Transcription of TAp63 and Suppresses Tumorigenesis
Fanconi Anemia (FA) is a rare genetic disorder characterized by an increased susceptibility to squamous cell cancers. Fifteen FA genes are known, and the encoded proteins cooperate in a common DNA repair pathway. A critical step is the monoubiquitination of the FANCD2 protein, and cells from most...
ORGANISM(S): Homo sapiens 
2013-06-27 | E-GEOD-46902 | biostudies-arrayexpress
TranscriptomicsOxymetholone therapy of Fanconi anemia suppresses osteopontin transcription and induces hematopoietic stem cell cycling
We used Fancd2-/- mice to understand its mechanism of action. Transcriptome analysis of cKit+ Sca1+ Lin- (KSL) cells discovered that only four genes changed their expression levels significantly after chronic OXM administration in both Fancd2−/− and wild-type mice: mKi67 and Cenpf were up-regualted ...
ORGANISM(S): Mus musculus 
2015-01-06 | E-GEOD-58724 | biostudies-arrayexpress
Proteomics293FT Cell Endogenous FANCA Protein-Protein Interactions
Hyperinsulinemia affects 72% of Fanconi anemia (FA) patients and an additional 25% experience lowered glucose tolerance or frank diabetes. The underlying molecular mechanisms contributing to the dysfunction of FA pancreas β cells is unknown. These experiments were performed in 293FT HEK cells as a p...
ORGANISM(S): Homo sapiens (Human) 
2019-07-25 | PXD010570 | Pride
Fanca Protein-protein interaction Fanconi anemia complementation group a 
UnknownIsolation of a cDNA representing the Fanconi anemia complementation group E gene.
Not available
S-EPMC1288571 | biostudies-literature
UnknownA human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M.
Not available
S-EPMC2704909 | biostudies-literature
GenomicsFanconi anemia
Non-invasive assessment of early embryonic somatic mosaicism and hypermutation phenomenon in patients with Fanconi anemia
PRJEB110758 | ENA
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