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Proteomics293FT Cell Endogenous FANCA Protein-Protein Interactions
Hyperinsulinemia affects 72% of Fanconi anemia (FA) patients and an additional 25% experience lowered glucose tolerance or frank diabetes. The underlying molecular mechanisms contributing to the dysfunction of FA pancreas β cells is unknown. These experiments were performed in 293FT HEK cells as a p...
ORGANISM(S): Homo sapiens (Human) 
2019-07-25 | PXD010570 | Pride
Fanca Protein-protein interaction Fanconi anemia complementation group a 
GenomicsCCH-SCC-FA1 FANCA-essentiality screen
CCH-SCC-FA1 FANCA-essentiality screen
PRJEB113221 | ENA
ProteomicsEndoC-betaH3 Cell FANCA Protein Interactions Regulated by Glucose Stimulation
Hyperinsulinemia affects 72% of Fanconi anemia (FA) patients and an additional 25% experience lowered glucose tolerance or frank diabetes. The underlying molecular mechanisms contributing to the dysfunction of FA pancreas β cells is unknown. Therefore, we sought to identify previously unexplored rol...
ORGANISM(S): Homo sapiens (Human) 
2019-07-25 | PXD010589 | Pride
Human Pancreas beta cell Glucose stimulation 
GenomicsKinome-wide shRNA screen for synthetic lethality in patient-derived FANCA-deficient fibroblasts.
The purpose of this screen was to identify synthetic lethal targets in FANCA-deficient cells.
ORGANISM(S): Homo sapiens 
2021-05-24 | E-MTAB-9802 | biostudies-arrayexpress
GenomicsAlisertib treatment in FANCA-deficient cell lines
Alisertib treatment in FANCA-deficient cell lines
PRJEB113242 | ENA
ProteomicsFANCA protein-protein interaction network
The objective of the project is to determine the interactome of FANCA in order to identify the partners and the biochemical and molecular pathways to which it contributes, which will be successively functionally analyzed by bioinformatics approaches and in living cells.
ORGANISM(S): Homo sapiens (Human) 
2026-08-05 | PXD068730 | Pride
Fanconi anemia Rna splicing Dna damage response Ribosome biogenesis 
GenomicsKinome-wide shRNA screen for synthetic lethality in patient-derived FANCA-deficient fibroblasts.
Kinome-wide shRNA screen for synthetic lethality in patient-derived FANCA-deficient fibroblasts.
PRJEB44964 | ENA
TranscriptomicsFANCA deficiency promotes leukemic progression by allowing emergence of cells carrying oncogenic driver mutations
Leukaemia is caused by the clonal evolution of a cell that accumulates mutations/genomic rearrangements, allowing unrestrained cell growth. However, recent identification of leukaemic mutations in the blood cells of healthy individuals revealed that additional events are required to expand the mutat...
ORGANISM(S): Mus musculus 
2023-08-31 | GSE164411 | GEO
GenomicsFANCA deficiency promotes leukemic progression by allowing emergence of cells carrying oncogenic driver mutations
FANCA deficiency promotes leukemic progression by allowing emergence of cells carrying oncogenic driver mutations
PRJNA690565 | ENA
UnknownRare variants in FANCA induce premature ovarian insufficiency.
Not available
S-EPMC6874525 | biostudies-literature
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