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TranscriptomicsSystematic Transcriptome Analysis of Zebrafish Model of Diamond-Blackfan Anemia from RPS24 Deficiency (mRNA-Seq)
In this study, we found RPS24 is required for both the primitive hematopoiesis and definitive hematopoiesis process partly mediated by P53 pathway. With the RNA-seq and miRNA-seq technique, several deregulated genes and miRNAs were found to be related with hematopoiesis, vascular development and apo...
ORGANISM(S): Danio rerio 
2015-05-18 | E-GEOD-54152 | biostudies-arrayexpress
TranscriptomicsSystematic Transcriptome Analysis of Zebrafish Model of Diamond-Blackfan Anemia from RPS24 Deficiency (miRNA-Seq)
In this study, we found RPS24 is required for both the primitive hematopoiesis and definitive hematopoiesis process partly mediated by P53 pathway. With the RNA-seq and miRNA-seq technique, several deregulated genes and miRNAs were found to be related with hematopoiesis, vascular development and apo...
ORGANISM(S): Danio rerio 
2015-05-18 | E-GEOD-54259 | biostudies-arrayexpress
TranscriptomicsAssessment of hematopoietic failure due to RPL11 deficiency in a zebrafish model of DiamondM-bM-^@M-^SBlackfan anemia by deep sequencing
To comprehensively reflect the impact of RPL11 deficiency on the transcriptome of zebrafish embryos, we collected 40M-bM-^@M-^S50 RPL11-deficient and MO control zebrafish embryos at 48 hpf from separate experiments and constructed two mRNA-seq sequencing libraries in parallel. High-throughput sequen...
ORGANISM(S): Danio rerio 
2014-01-21 | E-GEOD-51326 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of the Zebrafish model of Diamond-Blackfan Anemia from RPS19 deficiency via p53-dependent and -independent pathways
To determine the effect on the whole transcriptome of RPS19 morpholino and to identify the function of p53 in RPS19-deficient embryos, we analyzed the genome-wide transcript profiles of control morpholino (control), RPS19 morpholino knockdown (RPS19 MO), and RPS19 and p53 morpholino knockdown simult...
ORGANISM(S): Danio rerio 
2013-10-09 | E-GEOD-45699 | biostudies-arrayexpress
TranscriptomicsRNA-seq of control and foxo3b MO zebrafish cells.
Gata1+ cells isolated from control and foxo3b MO zebrafish at 24 and 48hpf were subjected to RNA-seq and related analyses. Gata1-GFP zebrafish stran was utilized, embryos were injected with foxo3b MO and standard MO at one-cell stage. Gata1+ cells were selected by FACS at 24 and 48hpf and submitted ...
ORGANISM(S): Danio rerio 
2015-08-04 | E-GEOD-66860 | biostudies-arrayexpress
TranscriptomicsCharacterization of miRNomes in acute and chronic myeloid leukemia cells
An in-depth analysis of miRNomes in 3 human myeloid leukemia cell lines was carried out to comprehensively identify miRNAs that distinguish acute and chronic myeloid leukemias and relate to myeloid cell differentiation. Characterization the miRNomes in 3 myeloid leukemia cell lines.
ORGANISM(S): Homo sapiens 
2014-07-03 | E-GEOD-48059 | biostudies-arrayexpress
TranscriptomicsDynamic transcriptomes during human erythroid differentiation and development
To explore the mechanisms controlling erythroid differentiation and development in human, we analyzed the genome-wide transcription dynamics that occurs during the differentiation of HESCs into the erythroid lineage and development of embryonic to adult erythropoiesis using high throughput sequencin...
ORGANISM(S): Homo sapiens 
2013-10-31 | E-GEOD-32991 | biostudies-arrayexpress
TranscriptomicsTranscriptomes of K562 cell line
To investigate the expression level of genes in K562 cells Profiling the transcriptome of K562
ORGANISM(S): Homo sapiens 
2013-07-15 | E-GEOD-39374 | biostudies-arrayexpress
TranscriptomicsDynamic transcriptomes of human myeloid leukemia cells
To identify the mechanisms controlling chronic myeloid leukemia (CML) and acute myeloid leukemia (AML) in humans, we analyzed genome-wide transcription dynamics in three myeloid leukemia cell lines (K562, HL-60, and THP1) using high-throughput sequencing technology. Using KEGG analysis, we found tha...
ORGANISM(S): Homo sapiens 
2013-10-09 | E-GEOD-46164 | biostudies-arrayexpress
TranscriptomicsMAGE-A1 Promotes Proliferation, Migration and Invasion of Human Melanoma Cells through RNA-SEQ Analysis via Affecting C-JUN-IL8-ARHGAP29 Network
To define the role of MAGE-A1 in melanoma growth and metastasis, we performed RNA-seq analysis on MAGE-A1 overexpression (OE) and knockdown (KD) models in A375 human melanoma cell line. Our results revealed that overexpression of MAGE-A1 dramatically promoted proliferation, migration, and invasion o...
ORGANISM(S): Homo sapiens 
2016-01-04 | E-GEOD-66859 | biostudies-arrayexpress
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