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GenomicsChip-Seq analysis of Sox2 protein genome-wide DNA binding sites in glioma cancer cells
We report here our results of the genome wide target identification of SOX2 in GBM cells by ChIP-seq analysis. Identification of Sox2 DNA binding site in glioma cancer cells
ORGANISM(S): Homo sapiens 
2011-01-10 | E-GEOD-23795 | biostudies-arrayexpress
TranscriptomicsGenes regulated by Sox2 in glioma cancer cell line
Knockdown of Sox2 in LN229 gliomal cancer cells decrease their growth rates in vitro. We used microarrays to detail the global programme of gene expression in Sox2 Knockdown LN229 cells compared with mock knockdown LN229 cells Sox2 knockdown LN229 cells and and mock knockdown LN229 cells were cultur...
ORGANISM(S): Homo sapiens 
2011-01-10 | E-GEOD-23838 | biostudies-arrayexpress
TranscriptomicsLong noncoding RNAs expression patterns associated with chemo response to cisplatin based chemotherapy in lung squamous cell carcinoma patients
There is large variability among lung squamous cell carcinoma (SCC) patients in response to treatment with cisplatin based chemotherapy. LncRNAs is potentional a new type of predictive marker that can identify subgroups of patients who benefit from chemotherapy and it will have great value for treat...
ORGANISM(S): Homo sapiens 
2015-05-18 | E-GEOD-59245 | biostudies-arrayexpress
ProteomicsQuantitative proteomics reveals the crucial roles of Cathepsin D in bacterial infections
Bacterial resistance has become more and more widespread which seriously threatens human life and health. Therefore, using the natural immune system of host to kill bacteria is particularly fascinating. Here, using mass spectrometry analyses, we depicted the dynamic expression landscape of mitochond...
ORGANISM(S): Mus Musculus 
PXD016938 |
ProteomicsLong term effects of ethanol intake on the CYP450 enzyme system in the liver of AFLD rats
Alcoholic fatty liver disease (AFLD) is a liver disease closely related to long-term alcohol consumption. Although it is known that liver microsomal cytochrome P450 enzyme (CYP450) plays a crucial role in metabolizing alcohol and various exogenous compounds, the specific mechanism by which alcohol a...
ORGANISM(S): Mus Musculus 
PXD063375 |
ProteomicsThe Dynll1-Cox4il Complex Regulates Intracellular Pathogen Clearance via Release of Mitochondrial Reactive Oxygen Species
Cellular membrane proteins are a critical part of the host defense mechanisms against infection and intracellular survival of Listeria monocytogenes. The complex spatiotemporal regulation of bacterial infection by various membrane proteins has been challenging to study. Here, using mass spectrometry...
ORGANISM(S): Mus Musculus 
2020-02-17 | PXD016452 |
ProteomicsSARS-CoV-2 ORF10 impairs cilia by enhancing CUL2ZYG11B activity
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causal pathogen of the ongoing global pandemic of coronavirus disease 2019 (COVID-19). Loss of smell and taste are new identified symptoms of COVID‐19, and both of these are related to cilia dysfunction. However, the pathological me...
ORGANISM(S): Homo Sapiens 
2022-02-23 | PXD031842 |
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