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TranscriptomicsTranscription profiling of effect of hypoxia in human primary monocytes
Experiment with 6 hybridizations, using 30 samples of species [Homo sapiens], using 6 arrays of array design [Affymetrix GeneChip Human Genome HG-U133A [HG-U133A]], producing 6 raw data files and 6 transformed and/or normalized data files.
ORGANISM(S): Homo sapiens 
2005-10-10 | E-MEXP-445 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human immature dendritic cells under hypoxic condition
Dendritic cells (DCs) are professional antigen-presenting cells whose activity is intrinsically linked to the microenvironment. Hypoxia is a condition of low oxygen tension occurring in inflammatory tissues that creates a special microenvironment conditioning cell physiology. We studied the effects ...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-6863 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human neuroblastoma cell lines grown under normoxic and hypoxic conditions
Hypoxia is a low oxygen condition that occurs in the developing tumor mass and that is associated with poor prognosis and resistance to chemo- and radio-therapy. The definition of the hypoxia gene signature is fundamental for the understanding of tumor biology, as in the case of neuroblastoma, the m...
ORGANISM(S): Homo sapiens 
2009-10-10 | E-GEOD-17714 | biostudies-arrayexpress
TranscriptomicsLenses expression profile of DBL oncogene transgenic mice
The Dbl family of proteins represents a large group of proto-oncogenes involved in cell growth regulation. Alterations of the normal function of these proteins lead to pathological processes such as developmental disorders and neoplastic transformation. We have generated transgenic mice introducing ...
ORGANISM(S): Mus musculus 
2009-06-01 | E-GEOD-15694 | biostudies-arrayexpress
TranscriptomicsBone marrows infiltrating human neuroblastoma cells express high levels of calprotectin and HLA-G proteins.
In neuroblastoma (NB) patients metastasis are the main cause of death, thus understanding the biological and genetic features of the metastatic NB cells is needed to reach efficient target-based therapies for high risk patients. In recent years, several prognostic signatures derived from gene expres...
ORGANISM(S): Homo sapiens 
2012-01-20 | E-GEOD-25623 | biostudies-arrayexpress
TranscriptomicsMature dendritic cells under hypoxic condition
Dendritic cells (DCs) are professional antigen-presenting cells whose activity is intrinsically linked to the microenvironment. Hypoxia is a condition of low oxygen tension occurring in inflammatory tissues that creates a special microenvironment conditioning cell physiology. We studied the effects ...
ORGANISM(S): Homo sapiens 
2010-12-31 | E-GEOD-22282 | biostudies-arrayexpress
TranscriptomicsThe bone marrow microenvironment in patients with neuroblastoma: presence of IFN signature and significant down-regulation of CXCL12 expression
Neuroblastoma (NB) is the most common extra cranial solid tumor in infants. Although several risk factors including patient age, disease stage and genetic abnormalities, such as MYCN amplification and 11q deletion, have been shown to predict outcome, the mechanisms responsible for the heterogeneous ...
ORGANISM(S): Homo sapiens 
2011-09-29 | E-GEOD-25624 | biostudies-arrayexpress
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