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UnknownFrailty Assessment for Risk prediction in Gynecologic Oncology patients undergoing surgery and chemotherapy (FARGO) study protocol: Rationale and design of a multi-centre prospective cohort study.
Not available
S-EPMC12303337 | biostudies-literature
GenomicsRapid transcription of arc/arg3.1 and other very fast immediate early genes in response to neuronal activity is mediated by a stalled RNA polymerase II mechanism
Transcription of immediate early genes (IEGs) in neurons is exquisitely sensitive to neuronal activity, but the mechanism underlying the earliest of these transcription events is largely unknown. Here we demonstrate that very fast IEGs (VF-IEGs) such as arc/arg3.1 are poised for rapid transcription ...
ORGANISM(S): Rattus norvegicus 
2011-05-24 | E-GEOD-22878 | biostudies-arrayexpress
GenomicsGlobal Analysis of Short RNAs Reveals Widespread Promoter-Proximal Stalling and Arrest of Pol II
We developed a novel approach to isolate and characterize, at nucleotide-level resolution, the RNAs derived from RNA polymerase II (Pol II) in early elongation complexes. We find that high numbers of these short RNAs are not correlated with gene expression but instead are indicative of promoter-prox...
ORGANISM(S): Drosophila melanogaster 
2009-12-11 | E-GEOD-18643 | biostudies-arrayexpress
TranscriptomicsUpstream Anti-sense Promoters Act as Local Enhancers of Mammalian Protein-coding Genes
Anti-sense transcription originating upstream of mammalian protein-coding genes is a well-documented phenomenon, but remarkably little is known about the function or regulation of these anti-sense promoters or the non-coding RNAs they generate. Here we define at nucleotide resolution the divergent t...
ORGANISM(S): Mus musculus 
2015-06-23 | E-GEOD-62151 | biostudies-arrayexpress
GenomicsERM-NM-1 and PolII ChIP seq from Mouse Uterus
To advance understanding of mechanisms leading to biological and transcriptional endpoints related to estrogen action in the mouse uterus, we have mapped ERM-NM-1 and RNA polymerase II binding sites using chromatin immunoprecipitation (ChIP) followed by sequencing of enriched chromatin fragments (Ch...
ORGANISM(S): Mus musculus 
2012-04-08 | E-GEOD-36455 | biostudies-arrayexpress
TranscriptomicsPost-transcriptional regulation of cell-cell interaction protein-encoding transcripts by Zfs1p in S. pombe
Members of the tristetraprolin (TTP) family of CCCH tandem zinc finger proteins can bind directly to AU-rich elements in mRNAs and promote transcript deadenylation and decay. The yeast Schizosaccharomyces pombe expresses a single TTP family member, Zfs1p, that has been linked to the mating response...
ORGANISM(S): Schizosaccharomyces pombe 
2012-11-06 | E-GEOD-35009 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of G. gallus mRNA-seq from cell line macrophages and embryonic fibroblasts
RNA samples from chicken (Gallus gallus) embryonic fibroblasts (sample ID: ES90) as well as from the HD11 chicken macrophage cell line (sample ID: ES91) were sequenced at the National Institutes of Health Intramural Sequencing Center (NISC) using the Illumina GAIIx technology running the standard CA...
ORGANISM(S): Gallus gallus 
2013-08-01 | E-MTAB-1479 | biostudies-arrayexpress
UnknownSynteny perturbations between wheat homoeologous chromosomes caused by locus duplications and deletions correlate with recombination rates.
Not available
S-EPMC196889 | biostudies-literature
GenomicsERa and PolII ChIP seq from KIKO mouse uterus
ChIP-seq from mice with DNA binding mutations in Esr1 (KIKO mouse). Estrogen Receptor M-NM-1 (ERM-NM-1) interacts with DNA, directly, or indirectly via other transcription factors, referred to as M-bM-^@M-^\tetheringM-bM-^@M-^]. Evidence for tethering is based on in vitro studies and a widely used M...
ORGANISM(S): Mus musculus 
2014-04-03 | E-GEOD-56466 | biostudies-arrayexpress
TranscriptomicsLow temperatures impact dormancy status, flowering competence, and transcript profiles in crown buds of leafy spurge.
Leafy spurge (Euphorbia esula) is an herbaceous perennial weed that produces vegetatively from an abundance of underground adventitious buds. The objectives of this study were to determine how mimicking natural seasonal conditions (photoperiod and temperature) under controlled environmental conditio...
ORGANISM(S): Euphorbia esula 
2010-05-19 | E-GEOD-19217 | biostudies-arrayexpress
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