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MetabolomicsMetabolome and transcriptome combined profiling reveals fluconazole resistance mechanisms of Trichosporon asahii and role of farnesol in fluconazole tolerance

Trichosporon asahii is a basidiomycete yeast that is pathogenic to humans and animals, and fluconazole-resistant strains have recently increased. Farnesol secreted by fungi is a factor that causes variations in fluconazole resistance; however, few studies have explored the underlying mec...

2023-11-20 | MTBLS7236 | MetaboLights
TranscriptomicsAnalysis of the transcriptional response of Candida parapsilosis following exposure to farnesol
We used the results of a genome sequence survey to design and manufacture partial genomic microarrays that were applied to determining the transcriptional response of C. parapsilosis to the presence of exogenous farnesol. Keywords: drug response, farnesol, Transcriptional profiling was performed fo...
ORGANISM(S): Candida parapsilosis 
2010-06-11 | E-GEOD-6318 | biostudies-arrayexpress
ProteomicsThe metacaspase Mca1p restricts O-glycosylation during farnesol-induced apoptosis in Candida albicans
Protein glycolysation is an essential posttranslational modification in eukaryotic cells. In pathogenic yeasts, it is involved in a large number of biological processes, such as protein folding quality control, cell viability and host/pathogen relationships. A link between protein glycosylation and ...
ORGANISM(S): Candida albicans (Yeast) 
2016-05-02 | PXD003677 | Pride
Candida albicans O-glycosylation Glycoproteomics Ssb1 N-glycosylation Metacaspase Bgl2 Farnesol Glycomics Cdc48 Aminoxytmt Erad Pdi1 Orbitrap fusion. Apoptosis Glycans quantification 
TranscriptomicsRegulation of gene expression in human T lymphoblastic leukemia Molt4 cells by farnesol
Gene expression profiles of Molt4 cells treated with DMCS (vehicle) or farnesol were compared to understand the mechanism by which farnesol induces apoptosis in these cells. Molt4 cells were treated with 75 uM farnesol for 4 hrs to compare with vehicle-treated Molt4 cells. RNA from three replicates ...
ORGANISM(S): Homo sapiens 
2014-05-01 | E-GEOD-46670 | biostudies-arrayexpress
TranscriptomicsAnalysis of the effect of the farnesol on transcript levels and polysome association in C. albicans
Farnesol is a quorum-sensing sesquiterpene alcohol that, via regulation of specific signalling and transcription components, inhibits filamentous growth in Candida. We have found that farnesol also inhibits translation at the initiation step. In contrast to fusel alcohols, that target the eukaryotic...
ORGANISM(S): Candida albicans 
2016-07-31 | E-MTAB-3843 | biostudies-arrayexpress
GenomicsTranscriptional profiling of the Candida auris response to exogenous farnesol exposure
Transcriptional profiling of the Candida auris response to exogenous farnesol exposure
PRJNA746543 | ENA
GenomicsFarnesol Targets the GSTP1/MAPK Axis to Inhibit Trauma-Induced Tendon Heterotopic Ossification
Farnesol Targets the GSTP1/MAPK Axis to Inhibit Trauma-Induced Tendon Heterotopic Ossification
PRJNA1414437 | ENA
GenomicsComparative transcriptional analysis of Candida auris biofilms following farnesol and tyrosol treatment
Comparative transcriptional analysis of Candida auris biofilms following farnesol and tyrosol treatment
PRJNA976246 | ENA
TranscriptomicsTranscription profiling of human lung carcinome calls treated WITH Farnesol reveals Farnesol-induced apoptosis IS coupled TO THE endoplasmic reticulum (ER) stress response
Farnesol (FOH) and other isoprenoid alcohols induce apoptosis in various carcinoma cells and inhibit tumorigenesis in several in vivo models. However, the mechanisms by which these isoprenoids mediate their effects are not yet fully understood. In this study, we show that FOH is effective inducer of...
ORGANISM(S): Mus musculus 
2008-04-07 | E-GEOD-7215 | biostudies-arrayexpress
GenomicsFarnesol brain transcriptomics in CNS inflammatory demyelination
Farnesol brain transcriptomics in CNS inflammatory demyelination
PRJNA976694 | ENA
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