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MetabolomicsLipidomics study of different fat deposition sites in wuzhishan pigs with double knockout of APOE/LDLR
Apolipoprotein E (APOE) and the low-density lipoprotein receptor (LDLR) play a key role in regulating lipoprotein transport and cholesterol homeostasis. However, their roles in porcine fat deposition and adipose tissue remodelling are not well understood. This study utilised wild-type (WT) and APOE/...
2026-09-09 | MTBLS15330 | MetaboLights
TranscriptomicsRainbow trout adipose tissue depots (VAT, SAT, IMAT) - mRNAs
The aim of this study was to characterize different adipose tissue depots in rainbow trout (Oncorhynchus mykiss) through the analysis of mRNA and miRNA expression profiles. Mature adipocytes were isolated from visceral (VAT), subcutaneous (SAT), and intramuscular (IMAT) adipose tissues, and RNA sequ...
ORGANISM(S): Oncorhynchus mykiss 
2026-01-12 | E-MTAB-16058 | biostudies-arrayexpress
ProteomicsExtended multiplexing of TMT labeling reveals age and high fat diet specific proteome changes in mouse epididymal adipose tissue
Age-related and/or high caloric intake driven changes in visceral adipose tissue contribute to the development of diabetes and cardiovascular disease. The lack of reliable, high-throughput methods to analyze the adipose tissue protein composition has limited our understanding of the protein network...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2018-07-03 | MSV000082569 | MassIVE
TranscriptomicsImmortalized clonal brown, beige and white adipose cell lines
Brown fat generates heat via the mitochondrial uncoupling protein UCP1, defending against hypothermia and obesity. Recent data suggest that there are two distinct types of brown fat: classical brown fat derived from a myf-5 cellular lineage and UCP1-positive cells that emerge in white fat from a non...
ORGANISM(S): Mus musculus 
2012-07-23 | E-GEOD-39562 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of adipose tissue from mesenteric and subcutaneous depots from 11beta-HSD1 knockout and wild type mice
Adipose tissue from mesenteric and subcutaneous depots from 11beta-HSD1 knockout (KO) and wild-type (WY) mice. Five biological replicates in each group: mesenteric KO, mesenteric WT, subcutaneous KO, subcutaneous WT.
ORGANISM(S): Mus musculus 
2009-03-31 | E-MEXP-1636 | biostudies-arrayexpress
TranscriptomicsShort-term, high fat-feeding-induced changes in white adipose tissue gene expression are highly predictive for long-term changes
Using standardized, semipurified diets is a crucial factor for reproducibility of experimental nutritional studies. For the purpose of comparability and integration of research, two European consortia, Mitofood and BIOCLAIMS, proposed an AIN-93-based standard reference diet, the standardized BIOCLAI...
ORGANISM(S): Mus musculus 
2013-08-27 | E-GEOD-38337 | biostudies-arrayexpress
TranscriptomicsLiver transcriptome comparison of divergently selected Lean and Fat mouse lines in cholesterol homeostasis, bile acids, glucose and lipoprotein metabolism
This study aimed to identify molecular basis of obesity-resistant mechanisms in the Lean line with the emphasis on lipid homeostasis. Expression profiling using custom Steroltalk v2 microarray demonstrated that Lean mice exhibit a higher hepatic expression of cholesterol synthesis genes compared to ...
ORGANISM(S): Mus musculus 
2011-10-16 | E-GEOD-24967 | biostudies-arrayexpress
TranscriptomicsEffect of rimonabant on gene expression of visceral and subcutaneous adipose tissues: high fat diet
Mice were fed for 6 months with a normal chow (NC) or a high fat diet (HFD). After 6 months of diet, high fat fed mice with Low, Medium and High body weight, but with similar glucose intolerance, were selected. These selected mice as well as NC mice were then treated with Rimonabant or Vehicle for 1...
ORGANISM(S): Mus musculus 
2008-12-14 | E-GEOD-11790 | biostudies-arrayexpress
TranscriptomicsComparative transcriptome analysis of various adipose depots in Hanwoo
*Background: Adipocytes mainly function as energy storage and endocrine cells. The amount and distribution of fat are important factor that influence the meat quality in the beef industry. Fat depot can be found around internal organ (ometal), beneath the skin (subcutaneous), and between muscles (...
ORGANISM(S): Bos taurus 
2013-07-25 | E-GEOD-39618 | biostudies-arrayexpress
TranscriptomicsEffects of selection on residual feed intake and diet on gene expression in pig subcutaneous adipose tissue
Transcriptional profiling in subcutaneous adipose tissue of 48 pigs aged (132 days of age) originated from two lines divergently selected for residual feed intake (RFI) : low-RFI pigs (RFIneg), high-RFI pigs (RFIpl). Both lines were offered isocaloric and isoproteic diets with contrasted energy sour...
ORGANISM(S): Sus scrofa 
2016-07-01 | E-GEOD-70836 | biostudies-arrayexpress
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