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ProteomicsFBXL12 degrades FANCD2 to regulate replication recovery and promote cancer cell survival under conditions of replication stress
Oncogene-induced replication stress constitutes an early obstacle for pre-cancerous cells to overcome to progress towards malignancy. Fanconi anaemia signalling represents a major genomic maintenance pathway that is activated in response to replication stress, impinging on stalled replication fork s...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD043637 | Pride
Scf ubiquitin ligase Fanconi anaemia Fancd2 Replication stress Fbxl12 
GenomicsFBXL12 degrades FANCD2 to regulate replication recovery and promote cancer cell survival under conditions of replication stress
FBXL12 degrades FANCD2 to regulate replication recovery and promote cancer cell survival under conditions of replication stress
PRJNA972728 | ENA
UnknownFbxl12 triggers G1 arrest by mediating degradation of calmodulin kinase I.
Not available
S-EPMC3905573 | biostudies-literature
UnknownAn SCF complex containing Fbxl12 mediates DNA damage-induced Ku80 ubiquitylation.
Not available
S-EPMC3594259 | biostudies-literature
TranscriptomicsFBXL12 degrades FANCD2 to regulate replication recovery and promote cancer cell survival under conditions of replication stress
Oncogene-induced replication stress constitutes an early obstacle for pre-cancerous cells to overcome to progress towards malignancy. Fanconi anaemia signalling represents a major genomic maintenance pathway that is activated in response to replication stress, impinging on stalled replication fork s...
ORGANISM(S): Homo sapiens 
2023-08-16 | GSE232558 | GEO
UnknownFBXL12 degrades FANCD2 to regulate replication recovery and promote cancer cell survival under conditions of replication stress.
Not available
S-EPMC10592106 | biostudies-literature
UnknownNotch and the pre-TCR coordinate thymocyte proliferation by induction of the SCF subunits Fbxl1 and Fbxl12.
Not available
S-EPMC6754294 | biostudies-literature
UnknownThe intronic region of Fbxl12 functions as an alternative promoter regulated by UV irradiation.
Not available
S-EPMC5668677 | biostudies-literature
ProteomicsFBXL12 degrades FANCD2 to regulate stalled fork recovery and promote cancer cell survival under conditions of replication stress
Oncogene-induced replication stress constitutes an early obstacle for pre-cancerous cells to overcome to progress towards malignancy. Fanconi anaemia signalling represents a major genomic maintenance pathway that is activated in response to replication stress, impinging on stalled replication fork s...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-05-22 | MSV000092004 | MassIVE
GenomicsMus musculus
FBXL12 Reorchestrated Microglial State to Inhibit Scarring and Achieve Adult Spinal Cord Injury Repair (PRJCA042426)
PRJDB38778 | ENA
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