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GenomicsFANCD2 Activates Transcription of TAp63 and Suppresses Tumorigenesis
Fanconi Anemia (FA) is a rare genetic disorder characterized by an increased susceptibility to squamous cell cancers. Fifteen FA genes are known, and the encoded proteins cooperate in a common DNA repair pathway. A critical step is the monoubiquitination of the FANCD2 protein, and cells from most...
ORGANISM(S): Homo sapiens 
2013-06-27 | E-GEOD-46902 | biostudies-arrayexpress
ProteomicsCrosslinking mass spectrometry (CLMS) analysis of monoubiquitinated FANCD2-FANCI complex
Vertebrate DNA crosslink repair excises toxic replication-blocking DNA crosslinks. Numerous factors involved in crosslink repair have been identified, and mutations in their corresponding genes cause Fanconi anemia (FA). A key step in crosslink repair is monoubiquitination of the FANCD2-FANCI hetero...
ORGANISM(S): Gallus gallus (Chicken) 
2020-03-09 | PXD017020 | Pride
Crosslinking mass spectrometry Fancd2-fanci comple Monoubiquitination Fanconi anemia pathway 
ProteomicsCrosslinking/mass spectrometry analysis of Fanconi anemia (FA) pathway FANCD2-FANCI complexes
DNA interstrand crosslinks (ICLs) are repaired by the Fanconi anemia (FA) pathway. The FA pathway is activated by phosphorylation of FANCI in FANCD2-FANCI complex. To investigate how phosphorylation regulates FA pathway activation and function, recombinant FANCD2-FANCI complexes prepared using eithe...
ORGANISM(S): Cellular Organisms 
2022-11-18 | PXD031632 | JPOST Repository
ProteomicsFBXL12 degrades FANCD2 to regulate replication recovery and promote cancer cell survival under conditions of replication stress
Oncogene-induced replication stress constitutes an early obstacle for pre-cancerous cells to overcome to progress towards malignancy. Fanconi anaemia signalling represents a major genomic maintenance pathway that is activated in response to replication stress, impinging on stalled replication fork s...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD043637 | Pride
Scf ubiquitin ligase Fanconi anaemia Fancd2 Replication stress Fbxl12 
GenomicsHematopoiesis in Murine Fancd2-/- vs WT Fetal Liver
Hematopoiesis in Murine Fancd2-/- vs WT Fetal Liver
PRJNA727546 | ENA
GenomicsEffect of SRSF1 depletion on FANCD2 mRNA and isoform expression and effect of FANCD2 depletion or expression of SRSF1 mutants on splicing
Effect of SRSF1 depletion on FANCD2 mRNA and isoform expression and effect of FANCD2 depletion or expression of SRSF1 mutants on splicing
PRJNA875477 | ENA
GenomicsFANCD2 Activates Transcription of TAp63 and Suppresses Tumorigenesis
Fanconi Anemia (FA) is a rare genetic disorder characterized by an increased susceptibility to squamous cell cancers. Fifteen FA genes are known, and the encoded proteins cooperate in a common DNA repair pathway. A critical step is the monoubiquitination of the FANCD2 protein, and cells from most FA...
ORGANISM(S): Homo sapiens 
2013-06-27 | GSE46902 | GEO
GenomicsGenome-wide maps of FANCD2 binding sites in untreated and aphidicolin-treated HCT116 cells.
Genome-wide maps of FANCD2 binding sites in untreated and aphidicolin-treated HCT116 cells.
PRJNA592085 | ENA
GenomicsFANCD2 restrains fork progression and prevents fragility at early origins upon re-replication
FANCD2 restrains fork progression and prevents fragility at early origins upon re-replication
PRJNA1201078 | ENA
TranscriptomicsEffect of SRSF1 depletion on FANCD2 mRNA and isoform expression and effect of FANCD2 depletion or expression of SRSF1 mutants on splicing
To investigate the cooperative function of FANCD2/SRSF1 complex in the regulation of R-loops, we performed gene expression, isoform and splicing analysis in Hela cells depleted of SRSF1 or expressing SRSF1 mutants and FA-D2 mutant (FA-D2) and wild type (FA-D2+FANCD2) cells.
ORGANISM(S): Homo sapiens 
2024-02-26 | GSE212471 | GEO
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