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ProteomicsComprehensive proteometics identifies FBXL6 substrates involved in liver cancer
FBXL6 is frequently over-expressed in human hepatocellular carcinoma (HCC). However, it is still unknown the underlying mechanisms by which FBXL6 promotes HCC. In this study, we compared ubiquitinated protein profiles among a panel of liver tissue samples (including HCC, adjacent tissues and normal...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-26 | PXD032357 | Pride
Hcc Mice Fbxl6 
ProteomicsThe E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins
Most mitochondrial proteins are synthetized in the cytosol and imported into mitochondria. Here, we demonstrate that the E3 ubiquitin ligase F-box/LRR-repeat protein 6 (FBXL6) controls the quality of newly synthesized mitochondrial ribosomal proteins in mammalian cells. We found that cells lacking F...
ORGANISM(S): Homo sapiens (Human) 
2025-09-17 | PXD028161 | Pride
Human Fbxl6 Turboid E3 ubiquitin ligase 
GenomicsFBXL6 promotes bladder cancer progression by stabilizing ENO1 through K63-linked ubiquitination
FBXL6 promotes bladder cancer progression by stabilizing ENO1 through K63-linked ubiquitination
PRJNA1255618 | ENA
ProteomicsProteomic analysis of FBXL6 interacting proteome
FBXL6 is a E3 ubiquitin ligase that we suspected to be involved in mitochondrial functions. We have investigated the specific interactome of this E3 by transfecting HEK cells with Flagged-FBXL6, or with b-gal (control). After flag immunoprecipiation, specific interacting proteome was identified by m...
ORGANISM(S): Homo sapiens (Human) 
2023-09-25 | PXD037248 | Pride
Quantitative proteome Human cell line Immunoprecipitation 
TranscriptomicsFBXL6 promotes bladder cancer progression by stabilizing ENO1 through K63-linked ubiquitination
Ubiquitin-mediated post-translational modifications play critical roles in tumor progression, yet their regulatory mechanisms in bladder cancer (BLCA) remain incompletely understood. Here, we identified FBXL6, belonging to the F-box protein family, as a potential oncogenic driver in BLCA through int...
ORGANISM(S): Homo sapiens 
2026-04-26 | GSE295700 | GEO
ProteomicsProteomic analysis of FBXL6 Knockdown cells proteome
FBXL6 is E3 ubiquitin ligase that we suspected to be involved in mitochondrial functions. We have investigated how deletion of this E3s by CRSIPR/Cas in Hela cells affects the cellular proteome. We compared this proteome to cells treated with CRISPR Non-Targeting Control (control cells).
ORGANISM(S): Homo sapiens (Human) 
2023-09-25 | PXD037252 | Pride
Quantitative proteome Human cell line 
UnknownFBXL6 degrades phosphorylated p53 to promote tumor growth.
Not available
S-EPMC8257708 | biostudies-literature
UnknownFBXL6 depletion restrains clear cell renal cell carcinoma progression.
Not available
S-EPMC9526225 | biostudies-literature
ProteomicsFBXL6 interactome analysis via AP-MS
Interactome analysis via AP-MS identify CatG (Cathepsin G) as a FBXL6 interactor.
ORGANISM(S): Homo sapiens (Human) 
2024-07-15 | PXD051269 | Pride
Ap-ms E3 ubiquitin ligase Interactome Aml 
UnknownFBXL6 governs c-MYC to promote hepatocellular carcinoma through ubiquitination and stabilization of HSP90AA1.
Not available
S-EPMC7310287 | biostudies-literature
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