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ProteomicsFBXO3-mediated DUSP9 ubiquitination promotes leukemia stem cell maintenance and tyrosine kinase inhibitor resistance in chronic myeloid leukemia
Eradicating leukemic stem cells (LSCs) and overcoming tyrosine kinase inhibitor (TKI) resistance is urgent for chronic myeloid leukemia (CML) treatment. We find that F-box protein 3 (FBXO3) is highly upregulated in CD34+ CML stem cells from TKI-resistant patients and identify it as an innovative CML...
ORGANISM(S): Homo sapiens (Human) 
2026-01-25 | PXD073522 | Pride
Tkis resistance Fbxo3 Cml-lscs Dusp9 Chronic myeloid leukemia 
GenomicsFBXO3-mediated DUSP9 ubiquitination reprograms MAPK signaling to eradicate tyrosine kinase inhibitor-resistant CML stem cells
FBXO3-mediated DUSP9 ubiquitination reprograms MAPK signaling to eradicate tyrosine kinase inhibitor-resistant CML stem cells
PRJNA1333896 | ENA
TranscriptomicsFBXO3-mediated DUSP9 ubiquitination reprograms MAPK signaling to eradicate tyrosine kinase inhibitor-resistant CML stem cells
Discovering new therapeutic targets to overcome tyrosine kinase inhibitors (TKIs) resistance and clear leukemic stem cells (LSCs) is an urgent clinical need for chronic myeloid leukemia (CML) treatment. In the present study, we report that the F-box protein 3 (FBXO3) is upregulated in CD34+ CML stem...
ORGANISM(S): Homo sapiens 
2026-01-18 | GSE309070 | GEO
UnknownFBXO3 stabilizes USP4 and Twist1 to promote PI3K-mediated breast cancer metastasis.
Not available
S-EPMC10745200 | biostudies-literature
UnknownTargeting F box protein Fbxo3 to control cytokine-driven inflammation.
Not available
S-EPMC3845358 | biostudies-literature
UnknownCrystal structure and interaction studies of the human FBxo3 ApaG domain.
Not available
S-EPMC5065005 | biostudies-literature
UnknownNoncanonical TGF-β signaling leads to FBXO3-mediated degradation of ΔNp63α promoting breast cancer metastasis and poor clinical prognosis.
Not available
S-EPMC7939357 | biostudies-literature
UnknownActivation of lysophagy by a TBK1-SCF<sup>FBXO3</sup>-TMEM192-TAX1BP1 axis in response to lysosomal damage.
Not available
S-EPMC11775327 | biostudies-literature
UnknownAn Amyotrophic Lateral Sclerosis-Associated Mutant of C21ORF2 Is Stabilized by NEK1-Mediated Hyperphosphorylation and the Inability to Bind FBXO3.
Not available
S-EPMC7481237 | biostudies-literature
UnknownBlocking the Spinal Fbxo3/CARM1/K+ Channel Epigenetic Silencing Pathway as a Strategy for Neuropathic Pain Relief.
Not available
S-EPMC8423947 | biostudies-literature
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