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ProteomicsDecreased Fc fucosylation aligns with enhanced RSV-specific antibody functionality in adults compared to young children
Respiratory syncytial virus (RSV) is a major cause of severe respiratory tract infections in infants and older adults. While vaccines have recently been approved for older adults and pregnant women, vaccine development for infants remains challenging due to the risk of vaccine-enhanced disease. Unde...
ORGANISM(S): Homo sapiens (Human) 
2025-11-05 | PXD069590 | Pride
Fc-glycosylation Antibody maturation Respiratory virus Fc-functionality 
UnknownCombinatorial Fc modifications for complementary antibody functionality.
Not available
S-EPMC11834420 | biostudies-literature
UnknownDecreased Fc fucosylation aligns with enhanced RSV-specific antibody functionality in adults compared to young children.
Not available
S-EPMC12748917 | biostudies-literature
UnknownA cyclic peptide-grafted Fc with hepatocyte growth factor functionality ameliorates hepatic fibrosis in a non-alcoholic steatohepatitis mouse model.
Not available
S-EPMC11300919 | biostudies-literature
GenomicsA cyclic peptide-grafted Fc with hepatocyte growth factor functionality ameliorates hepatic fibrosis in a non-alcoholic steatohepatitis mouse model.
A cyclic peptide-grafted Fc with hepatocyte growth factor functionality ameliorates hepatic fibrosis in a non-alcoholic steatohepatitis mouse model.
PRJNA974837 | ENA
UnknownInfluenza hemagglutinin-specific IgA Fc-effector functionality is restricted to stalk epitopes.
Not available
S-EPMC7923359 | biostudies-literature
UnknownFunctional, Biophysical, and Structural Characterization of Human IgG1 and IgG4 Fc Variants with Ablated Immune Functionality.
Not available
S-EPMC6698826 | biostudies-literature
TranscriptomicsA cyclic peptide-grafted Fc with hepatocyte growth factor functionality ameliorates hepatic fibrosis in a non-alcoholic steatohepatitis mouse model.
Although growth factors have significant therapeutic potential because of their regenerative functions, their poor pharmacokinetics and low stability hinder their therapeutic application. Nonalcoholic steatohepatitis (NASH) is characterized by lipid accumulation, inflammation, and fibrosis in the li...
ORGANISM(S): Mus musculus 
2024-07-04 | GSE233051 | GEO
UnknownMining HIV controllers for broad and functional antibodies to recognize and eliminate HIV-infected cells.
Not available
S-EPMC8196545 | biostudies-literature
UnknownGlycosylation engineering of therapeutic IgG antibodies: challenges for the safety, functionality and efficacy.
Not available
S-EPMC5777974 | biostudies-literature
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