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TranscriptomicsWhole Genome Exon Arrays Identify Differential Expression of Alternatively Spliced, Cancer-related Genes in Lung Cancer
Alternative processing of pre-mRNA transcripts is a major source of protein diversity in eukaryotes and has been implicated in several disease processes including cancer. In this study we have performed a genome wide analysis of alternative splicing events with the GeneChip Human Exon 1.0 ST Array f...
ORGANISM(S): Homo sapiens 
2008-10-17 | E-GEOD-12236 | biostudies-arrayexpress
GenomicsComparative methylome analysis of benign and malignant peripheral nerve sheath tumors
Aberrant DNA methylation (DNAm) was first linked to cancer over 25 years ago. Since then, many studies have associated hypermethylation of tumour suppressor genes and hypomethylation of oncogenes to the tumourigenic process. However, most of these studies have been limited to the analysis of promote...
ORGANISM(S): Homo sapiens 
2011-01-01 | E-GEOD-21714 | biostudies-arrayexpress
TranscriptomicsCNA profiling using high-density DNA methylation arrays (SNP array)
The integration of genomic and epigenomic data is becoming increasingly popular as we try to gain better understanding of the complex mechanisms driving the development and progression of cancer. However, this results in increased cost and sample depletion, the latter being particularly important wh...
ORGANISM(S): Homo sapiens 
2016-05-31 | E-GEOD-48941 | biostudies-arrayexpress
GenomicsMethylome Analysis of FF HPV+ and HPV- HNSCC samples
The analysis of the 6 methylomes by MeDIP-Seq comprise 3 HPV+ HNSCC samples and 3 HPV- HNSCC samples Analysis of the 6 methylomes, comprising 3 HPV+ HNSCC samples and 3 HPV- HNSCC samples
ORGANISM(S): Homo sapiens 
2012-11-01 | E-GEOD-38263 | biostudies-arrayexpress
TranscriptomicsRNA-seq of BMP response in glioblastoma-derived neural stem cells
The transcriptional response of normal and glioblastoma-derived neural (GNS) cells was profiled in self-renewing conditions and over a time course of differentiation in the presence of bone morphogenic protein (BMP).
ORGANISM(S): Homo sapiens 
2015-10-02 | E-MTAB-3867 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression profiling of normal and glioblastoma-derived neural stem cells
MicroRNA analysis of glioblastoma-derived neural stem (GNS) cells performed in parallel with normal neural stem (NS) cell lines
ORGANISM(S): Homo sapiens 
2016-11-01 | E-MTAB-3865 | biostudies-arrayexpress
TranscriptomicsHumanMethylation450 (450k) data for 79 rheumatoid arthritis disease discordant monozygotic twin pairs
This project contains genome-wide DNA methylation data generated using the HumanMethylation450 BeadChip (Illumina), for 79 rheumatoid arthritis (RA) discordant monozygotic twin pairs. By investigating disease discordant monozygotic twins, DNA methylation can be assessed without the confounding influ...
ORGANISM(S): Homo sapiens 
2018-07-24 | E-MTAB-6988 | biostudies-arrayexpress
GenomicsBLUEPRINT DNA methylation profiles of graft donors in allogenic hematopoietic stem cell transplantation
Allogenic hematopoietic stem cell transplantation (HSCT) is a curative treatment for many hematological conditions. Acute graft-versus-host disease (aGVHD) is a prevalent immune-mediated complication following HSCT. Current diagnostic biomarkers that correlate with aGVHD severity, progression, and t...
EGAS00001001287 | EGA
GenomicsATAC-seq of BMP response in glioblastoma-derived neural stem cells
Chromatin accessibility was profiled by ATAC-seq in normal and glioblastoma-derived neural stem (GNS) cells, in self-renewing conditions and in response to differentiation stimulus with bone morphogenic protein (BMP).
ORGANISM(S): Homo sapiens 
2015-10-01 | E-MTAB-3868 | biostudies-arrayexpress
TranscriptomicsHigh-resolution methylation profiling of glioblastoma neural stem cells and reprogrammed derivatives
Glioblastoma-derived neural stem (GNS) cells were reprogrammed to induced pluripotent stem (iPS) cells by transgenic expression of OCT4 and KLF4. Genome-wide DNA methylation status was profiled at 485,000 loci to assess epigenetic erasure and restoration due to reprogramming and redifferentiation to...
ORGANISM(S): Homo sapiens 
2013-03-15 | E-MTAB-1271 | biostudies-arrayexpress
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