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ProteomicsTargeting ATP2B1 impairs PI3K/Akt/Forkhead box (Fox) transcription factor signaling and reduces SARS-COV-2 infection and replication.
De Antonellis et al. shows the importance of the Ca2+ channel pump ATP2B1 in the regulation of intracellular Ca2+ levels that positively influence SARS-CoV-2 replication in human cells. Our study identifies the mechanism of action of SARS-CoV-2 in the regulation of the expression of ATP2B1 and ATP2A...
ORGANISM(S): Homo sapiens (Human) 
2024-05-17 | PXD051059 | Pride
Pi3k/akt Sars-cov-2 Atp2a1 Atp2b1 Ca2+ Forkhead box (fox) transcription factor Endoplasmic reticulum 
UnknownBiomarker analysis of the MITO2 phase III trial of first-line treatment in ovarian cancer: predictive value of DNA-PK and phosphorylated ACC.
Not available
S-EPMC5341934 | biostudies-literature
UnknownPerspective use of bio-adhesive liquid crystals as ophthalmic drug delivery systems.
Not available
S-EPMC10533901 | biostudies-literature
MetabolomicsOmics analysis in truffle (Tuber magnatum Pico): comparison of samples from different regions of Italy and from different seasons
Truffles are among the most expensive foods available in the market, usually used as flavoring additives for their distinctive aroma. The most valuable species is Tuber magnatum Pico, better known as 'Alba white truffle', in which bis(methylthio)methane is the key aroma compound. Given the high econ...
2020-12-10 | MTBLS808 | MetaboLights
UnknownThe use of esketamine in comorbid treatment resistant depression and obsessive compulsive disorder following extensive pharmacogenomic testing: a case report.
Not available
S-EPMC8444432 | biostudies-literature
TranscriptomicsRelevance of Chromosome 2p Gain in Early Binet Stage A Chronic Lymphocytic Leukemia (SNP)
Chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease characterized by chromosomal aberrations of prognostic significance. Recent studies showed that gain of chromosome 2p is a recurrent lesion in CLL. We investigated the 2p gain and its relationship with prognostic biomarkers in ...
ORGANISM(S): Homo sapiens 
2012-10-12 | E-GEOD-38613 | biostudies-arrayexpress
UnknownVandetanib in patients with locally advanced or metastatic medullary thyroid cancer: a randomized, double-blind phase III trial.
Not available
S-EPMC3675689 | biostudies-literature
UnknownThe neutrophil to lymphocyte ratio (NLR) and the presence of large nodal mass are independent predictors of early response: A subanalysis of the prospective phase II PET-2-adapted HD0607 trial.
Not available
S-EPMC7724487 | biostudies-literature
UnknownPlaying with opening and closing of heterocycles: using the cusmano-ruccia reaction to develop a novel class of oxadiazolothiazinones, active as calcium channel modulators and P-glycoprotein inhibitors.
Not available
S-EPMC6271282 | biostudies-literature
UnknownSterile inflammation via TRPM8 RNA-dependent TLR3-NF-B/IRF3 activation promotes antitumor immunity in prostate cancer
Not available
S-SCDT-10_1038-S44318-024-00040-5 | biostudies-other
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