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TranscriptomicsMicroRNA-15/16 Antagonizes c-Myb to Control Natural Killer Cell Maturation
NK cells develop in the bone marrow and complete their maturation in peripheral organs, but the molecular events controlling maturation are incompletely understood. Utilizing an NK cell-specific miR-15/16 deficient genetic model (15aKO), we identified a critical role for miR-15/16 family microRNAs i...
ORGANISM(S): Mus musculus 
2015-09-03 | E-GEOD-55033 | biostudies-arrayexpress
TranscriptomicsMicroRNA-15/16 Antagonizes c-Myb to Control Natural Killer Cell Maturation (c-Myb overexpression)
NK cells develop in the bone marrow and complete their maturation in peripheral organs, but the molecular events controlling maturation are incompletely understood. Utilizing an NK cell-specific miR-15/16 deficient genetic model (15aKO), we identified a critical role for miR-15/16 family microRNAs i...
ORGANISM(S): Mus musculus 
2015-09-03 | E-GEOD-58268 | biostudies-arrayexpress
TranscriptomicsNext-generation sequencing identifies the natural killer cell microRNA transcriptome
Natural killer (NK) cells are innate lymphocytes important for early host defense against infectious pathogens and surveillance against malignant transformation. Resting murine NK cells regulate the translation of effector molecule mRNAs (e.g. granzyme B, GzmB) through unclear molecular mechanisms....
ORGANISM(S): Mus musculus 
2010-10-01 | E-GEOD-21003 | biostudies-arrayexpress
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