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TranscriptomicsRequirement for flap endonuclease 1 (FEN1) to maintain genomic stability and transcriptional gene silencing in Arabidopsis
As a central component during Okazaki fragment maturation, flap endonuclease 1 (FEN1) removes the 5’ flap and maintains genomic stability. Here, FEN1 was cloned as a suppressor of transcriptional gene silencing (TGS) from a forward genetic screen. FEN1 is abundant in the root and shoot apical meri...
ORGANISM(S): Arabidopsis thaliana 
2016-05-28 | E-GEOD-79738 | biostudies-arrayexpress
ProteomicsCas1 and Fen1 Display Commutable Functions During Archaeal DNA Damage Repair
CRISPR-Cas constitutes an adaptive prokaryotic defence system against invasive nucleic acids like viruses and plasmids. Beyond their role in immunity, CRISPR-Cas systems have been shown to closely interact with components of cellular DNA repair pathways either by regulating their expression or via d...
ORGANISM(S): Haloferax volcanii DS2 
2022-05-20 | PXD029952 | Pride
Crispr Fen1 Archaea Dna damage Cas1 
GenomicsThioclava electrotropha ElOx9, Idiomarina strain FeN1
Transcriptomic investigation of Thioclava electrotropha strain ElOx9 and Idiomarina strain FeN1
PRJNA1293320 | ENA
UnknownThe FEN1 E359K germline mutation disrupts the FEN1-WRN interaction and FEN1 GEN activity, causing aneuploidy-associated cancers.
Not available
S-EPMC4160428 | biostudies-literature
TranscriptomicsRequirement for flap endonuclease 1 (FEN1) to maintain genomic stability and transcriptional gene silencing in Arabidopsis
As a central component during Okazaki fragment maturation, flap endonuclease 1 (FEN1) removes the 5’ flap and maintains genomic stability. Here, FEN1 was cloned as a suppressor of transcriptional gene silencing (TGS) from a forward genetic screen. FEN1 is abundant in the root and shoot apical merist...
ORGANISM(S): Arabidopsis thaliana 
2016-05-28 | GSE79738 | GEO
GenomicsDNA structure-specific endonuclease FEN1 as a novel drug target in tamoxifen resistant breast cancer.
Estrogen receptor α (ERα) is a key transcriptional regulator in the majority of breast cancers. ERα-positive patients are frequently treated with tamoxifen, but resistance is common. In this study, we refined a previously identified 111-gene outcome prediction-classifier, revealing FEN1 as the stron...
ORGANISM(S): Homo sapiens 
2020-06-01 | GSE95302 | GEO
GenomicsOverexpression of androgen receptor enhances the binding of the receptor to the chromatin in prostate cancer
Androgen receptor (AR) is overexpressed in the majority of castration-resistant prostate cancers (CRPCs). Our goal was to study the effect of AR overexpression on the chromatin binding of the receptor and to identify AR target genes that may be important in the emergence of CRPC. We have established...
ORGANISM(S): Homo sapiens 
2013-06-27 | E-GEOD-48308 | biostudies-arrayexpress
GenomicsFunctional link between Rad2 and Mediator
In this study, we generate genomic maps of Mediator, Rad2, Pol II, TBP and TFIIH, by ChIP coupled to next generation sequencing technology (ChIP-seq), in wild type strains from Saccharomyces cerevisiae. A related study involving ChIP-chip analysis of Rad2 occupany is also deposited at ArrayExpress ...
ORGANISM(S): Saccharomyces cerevisiae 
2013-12-01 | E-MTAB-1595 | biostudies-arrayexpress
GenomicsIntranasal administration of a multiplex targeting SCLMs@FEN1-hpDNAs with synergistic baicalein for pulmonary anti-viral treatment
Intranasal administration of a multiplex targeting SCLMs@FEN1-hpDNAs with synergistic baicalein for pulmonary anti-viral treatment
PRJNA1199957 | ENA
UnknownFEN1 Inhibition as a Potential Novel Targeted Therapy against Breast Cancer and the Prognostic Relevance of FEN1.
Not available
S-EPMC10889347 | biostudies-literature
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