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MetabolomicsTherapeutic effects of traditional Chinese medicine compound Hua-Feng-Dan in a rat model of ischemic stroke involve renormalization of gut microbiota

Hua-Feng-Dan is a traditional Chinese medicine compound used to treat ischemic stroke, but little is known about its therapeutic mechanism. This study explored whether and how the mechanism involves readjustment of gut microbiota. Rats were subjected to middle cerebral artery occlusion as a model...

2025-01-06 | MTBLS10818 | MetaboLights
ProteomicsRattus norvegicus lung LC-MS/MS
Male Sprague-Dawley rats were used to establish exhausted-exercise model by motorized rodent treadmill. Yu-Ping-Feng-San at doses of 2.18 g/kg was administrated by gavage before exercise training for 10 consecutive days. Quantitative proteomics was performed for assessing the related mechanism of Yu...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-08-12 | PXD032737 | Pride
Rattus norvegicus Lung tissue Lc-ms/ms 
GenomicsDNA 5-methylcytosine regulates genome-wide formation of G-quadruplex structures [WGBS]
DNA 5-methylcytosine regulates genome-wide formation of G-quadruplex structures [WGBS]
PRJNA1124892 | ENA
GenomicsDNA 5-methylcytosine regulates genome-wide formation of G-quadruplex structures [CUT&TAG]
DNA 5-methylcytosine regulates genome-wide formation of G-quadruplex structures [CUT&TAG]
PRJNA914300 | ENA
GenomicsDNA 5-methylcytosine regulates genome-wide formation of G-quadruplex structures [CUT&Tag]
DNA 5-methylcytosine regulates genome-wide formation of G-quadruplex structures [CUT&Tag]
PRJNA1124891 | ENA
GenomicsDNA 5-methylcytosine regulates genome-wide formation of G-quadruplex structures [RNA-seq]
DNA 5-methylcytosine regulates genome-wide formation of G-quadruplex structures [RNA-seq]
PRJNA914301 | ENA
GenomicsDNA 5-methylcytosine regulates genome-wide formation of G-quadruplex structures [ATAC-seq]
DNA 5-methylcytosine regulates genome-wide formation of G-quadruplex structures [ATAC-seq]
PRJNA1124893 | ENA
MetabolomicsA novel strategy for mining and identification of acylcarnitines using data-independent-acquisition (DIA) based retention time prediction modeling and pseudo-characteristic fragmentation ions matching
It is a challenging work to screen, identify, and quantify acylcarnitines in complex biological samples. A method, based on the retention time (RT) prediction and data-independent acquisition strategies, was proposed for the large-scale identification of acylcarnitines using liquid chromatography co...
2021-10-06 | MTBLS1932 | MetaboLights
UnknownLow G preconditioning reduces liver injury induced by high +Gz exposure in rats.
Not available
S-EPMC4458764 | biostudies-literature
ProteomicsCharacterizations of G-quadruplex RNA-Protein Interactions in Living Cells
RNA guanine quadruplexes (rG4s) are non-canonical nucleic acid structures essential for various cellular functions and disease pathways. Characterizing rG4-interacting proteins (rG4IPs) is crucial for deciphering biological roles of rG4s. Building upon the RNA-protein interaction detection (RaPID) m...
ORGANISM(S): Homo sapiens (Human) 
2026-06-01 | PXD070623 | Pride
G-quadruplex Rna-protein interactions Proteomics Lc-ms/ms 
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