Sort   by:  
 Page size 
MetabolomicsGluconeogenesis using glycerol as a substrate in bloodstream-form Trypanosoma brucei
Bloodstream form African trypanosomes are thought to rely exclusively upon glycolysis, using glucose as a substrate, for ATP production. Indeed, the pathway has long been considered a potential therapeutic target to tackle the devastating and neglected tropical diseases caused by these parasites. Ho...
2018-12-10 | MTBLS706 | MetaboLights
ProteomicsA high-confidence glycosome proteome for procyclic form Trypanosoma brucei by epitope-tag organelle enrichment and SILAC
Epitope tagging and magnetic bead enrichment were combined with SILAC quantitative proteomics to determine a high-confidence glycosome proteome for the procyclic life cycle stage of the parasite Trypanosoma brucei.
ORGANISM(S): Trypanosoma brucei 
2014-05-13 | PXD000663 | Pride
Trypanosoma brucei Orbitrap velos Ap-ms 
ProteomicsCell differentiation in Trypanosoma brucei is a bistable developmental switch requiring new protein synthesis to achieve signal memory
The life cycle of Trypanosoma brucei involves several cell differentiation transitions that allow transmission, survival and proliferation of these parasites. One of these transitions, the differentiation of growth-arrested stumpy forms in the mammalian blood into proliferating insect-stage procycli...
ORGANISM(S): Trypanosoma brucei 
2018-05-08 | PXD002165 | Pride
Phosphoproteomics Silac Differentiation Trypanosoma brucei 
Genomicsba3dbe29-0fd7-4ee5-99b8-d69d3c381e6e - samples
The BAM files for WES and RNA seq used in the article "Molecular Profiling Reveals Unique Immune and Metabolic Features of Melanoma Brain Metastases." on cancer Discovery 2019. PMID: 30787016 PMCID: PMC6497554. Authors : Grant M Fischer, ..., Michael A Davies.
EGAD00001005046 | EGA
OtherComparative SILAC proteomic analysis of Trypanosoma brucei bloodstream and procyclic lifecycle stages.
RANCHE KEY: 6rtELh46IFS7gExEGuFR7E2t3UZABvuzvkh0U5sz71SSZM+XogXG2a8Omdg5+KWQCmjpP30xZWhujBngVbaqsT9ZTpYAAAAAAAAGCw== Original data file: BSF-F3-7.mgf. Data published as part of PLoS One. 2012;7(5):e36619 . From the Abstract: {{i}} ... We have optimized a procedure for growing Trypanosoma brucei pro...
ORGANISM(S): Trypanosoma_brucei_ncbi 
GPM11210003129 | GPMDB
ProteomicsComparative phosphoproteome of Trypanosoma brucei bloodstream & procyclic form
Comparative phosphoproteomic analysis of SILAC labelled cultured bloodstream and procyclic form Trypansoma brucei. Phosphopeptide enrichement via SCX and TiO2, acquired on Oribtrap Velos using MSA. Triplicate biological replicate for each lifecycle stage (as unmixed, and two SILAC label swap expreim...
ORGANISM(S): Trypanosoma brucei 
2013-07-03 | PXD000049 | Pride
Trypanosoma brucei Silac Phosphoproteome 
ProteomicsGlobal Membrane Protein Interactome Analysis using In vivo Crosslinking and MS-based Protein Correlation Profiling
We present a methodology using in vivo crosslinking combined with HPLC-MS for the global analysis of endogenous protein complexes by protein correlation profiling. Formaldehyde crosslinked protein complexes were extracted with high yield using denaturing buffers that maintained complex solubility du...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-08-02 | MSV000080014 | MassIVE
ProteomicsT.brucei - Whole organism, sequence+MS2 intensity (Urbaniaketal,jproteomeres2013)
abundance based on sequence+MS2 intensity, Interaction consistency score: 17.4, Coverage: 56
ORGANISM(S): 5691 
2013-00-00 | 4181687758 | PAXDB
ProteomicsT.brucei - Whole organism, sequence+MS2 intensity (Urbaniaketal,jproteomeres2013)
abundance based on sequence+MS2 intensity, Interaction consistency score: 17.7, Coverage: 56
ORGANISM(S): 5691 
2013-00-00 | 4092869827 | PAXDB
MetabolomicsCell-based and multi-omics profiling reveal dynamic metabolic repurposing of mitochondria to drive developmental progression of Trypanosoma brucei

Mitochondrial metabolic remodeling is a hallmark of the Trypanosoma brucei digenetic life cycle since the insect stage utilizes the cost-effective oxidative phosphorylation to generate ATP, while bloodstream cells switch to less energetically efficient aerobic glycolysis. Due to difficulties in a...

2020-08-20 | MTBLS1390 | MetaboLights
Sort   by:  
 Page size