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MetabolomicsMetabolic Drug Response Phenotyping in Colorectal Cancer Organoids by LC-QTOF-MS
As metabolic rewiring is crucial for cancer cell proliferation, metabolic phenotyping of patient-derived organoids is desirable to identify drug-induced changes and trace metabolic vulnerabilities of tumor subtypes. We established a novel protocol for metabolomic and lipidomic profiling of colorecta...
2021-10-12 | MTBLS2130 | MetaboLights
TranscriptomicsColonic gene expression data of TIMP1 knock out colitis mice
Increased levels of tissue inhibitor of metalloproteinase-1 (TIMP-1) have been detected in fibrotic strictures in Crohn’s disease. In a murine model of chronic inflammation, fibrosis was associated with an increase in TIMP-1 and inhibition of matrix metalloproteinase (MMP)-mediated degradation. We...
ORGANISM(S): Mus musculus 
2016-07-22 | E-GEOD-73424 | biostudies-arrayexpress
TranscriptomicsColonic gene expression data of acute and chronic dextran sodium sulphate (DSS) colitis mice
The lack of suitable animal models reflecting chronically relapsing inflammation and tissue remodeling have hindered fibrosis research in inflammatory bowel diseases (IBD). This study investigated changes in connective tissue in a chronic murine model using different cycles of dextran sodium sulphat...
ORGANISM(S): Mus musculus 
2013-09-03 | E-GEOD-42768 | biostudies-arrayexpress
TranscriptomicsRNA-sequencing of inflamed intestinal mucosa of inflammatory bowel disease patients
Studying differences in responders and non-responders to therapy in inflammatory bowel disease (IBD) patients (crohn's disease and ulcerative colitis)
ORGANISM(S): Homo sapiens 
2019-01-24 | E-MTAB-7604 | biostudies-arrayexpress
TranscriptomicsPredicting response to vedolizumab therapy using mucosal transcriptomics in IBD patients
In this study we wanted to identify baseline predictors of successful vedolizumab therapy in patients with inflammatory bowel disease.
ORGANISM(S): Homo sapiens 
2019-08-23 | E-MTAB-7845 | biostudies-arrayexpress
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