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UnknownSARS-CoV-2 antibody dynamics in blood donors and COVID-19 epidemiology in eight Brazilian state capitals: A serial cross-sectional study.

Background

The COVID-19 situation in Brazil is complex due to large differences in the shape and size of regional epidemics. Understanding these patterns is crucial to understand future outbreaks of SARS-CoV-2 or other respiratory pathogens in the country.

Methods

We tested 97,950 blo...
S-EPMC9545556 | biostudies-literature
UnknownAntimicrobial activity and biocompatibility of alpha-silver tungstate nanoparticles.
The growing global threat posed by microorganisms resistant to conventional antimicrobials underscores the urgent need for novel agents to control infections. The aim of this study was to evaluate the antimicrobial activity and biocompatibility of alpha-silver tungstate (α-Ag2WO4
S-EPMC11891672 | biostudies-literature
UnknownAssessment of immune responses to a Comirnaty® booster following CoronaVac® vaccination in healthcare workers.

Background

The immunological response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and immunisation is variable.

Objectives

To describe the humoral immune response by correlating IgA and IgG antibodies with NAbs titration following CoronaVac® immunisation ...
S-EPMC11385826 | biostudies-literature
UnknownSequence analysis of the cDNA encoding for SpCTx: a lethal factor from scorpionfish venom (Scorpaena plumieri).

Background

Lethal factors are multifunctional oligomeric proteins found in the venomous apparatus of Scorpaeniformes fish. These toxins elicit not only an array of biological responses in vitro but also cardiovascular disorders and strong hemolytic, nociceptive and edematogenic activities in...
S-EPMC6114736 | biostudies-literature
UnknownThe diverse mechanisms and anticancer potential of naphthoquinones.
Cancer is one of the leading causes of death around the world and although the different clinical approaches have helped to increase survival rates, incidence is still high and so its mortality. Chemotherapy is the only approach which is systemic, reaching cancer cells in all body tissues and the se...
S-EPMC6679553 | biostudies-literature
UnknownLight-Emitting Porphyrin Derivative Obtained from a Subproduct of the Cashew Nut Shell Liquid: A Promising Material for OLED Applications.
In this work, the meso-tetra[4-(2-(3-n-pentadecylphenoxy)ethoxy]phenylporphyrin (H₂P), obtained from the cashew nut shell liquid (CNSL), and its zinc (ZnP) and copper (CuP) metallic complexes, were applied as emitting layers in organic light emitting diodes (OLEDs). These compounds were chara...
S-EPMC6479845 | biostudies-literature
UnknownIgA quantification as a good predictor of the neutralizing antibodies levels after vaccination against SARS-CoV-2.

Background

Vaccination against COVID-19 was implemented very quickly, but the emergence of new variants that can evade the previous acquired immunological protection highlights the importance of understanding the mechanisms involved in the immune response generated after SARS-CoV-2 infection...
S-EPMC9635250 | biostudies-literature
Unknown2-aminobenzimidazoles for leishmaniasis: From initial hit discovery to in vivo profiling.
Leishmaniasis is a major infectious disease with hundreds of thousands of new cases and over 20,000 deaths each year. The current drugs to treat this life-threatening infection have several drawbacks such as toxicity and long treatment regimens. A library of 1.8 million compounds, from which the hit...
S-EPMC7932521 | biostudies-literature
UnknownEpidemiological characterization of rare diseases in Brazil: A retrospective study of the Brazilian Rare Diseases Network.

Background

The Brazilian Policy for Comprehensive Care for People with Rare Diseases was implemented in 2014; however, national epidemiological data on rare diseases (RDs) are scarce and mainly focused on specific disorders. To address this gap, University Hospitals, Reference Services for N...
S-EPMC11523578 | biostudies-literature
UnknownSynthesis and biological evaluation of N-alkyl naphthoimidazoles derived from β-lapachone against Trypanosoma cruzi bloodstream trypomastigotes.
The QSAR study of 34 2-aryl-naphthoimidazoles screened so far revealed that σi is the most important factor for their lytic activity on the bloodstream trypomastigote forms of T. cruzi, the etiologic agent of Chagas disease. Based on this result, 16 new N-alkyl-naphth...
S-EPMC6071937 | biostudies-literature
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